H. Pylori

Card Set Information

Author:
ehamm
ID:
117519
Filename:
H. Pylori
Updated:
2011-11-17 12:59:03
Tags:
Pylori
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Description:
H. Pylori
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  1. Organism
    • Similar to campylobacter
    • Urease allows to exist in low pH
    • Vacuolating cytotoxin causes apoptosis -> large cytoplasmic vacules
    • Pathogenicity islands
    • Cag: injected protein associated with virulence
  2. Epidemiology
    • Very prevalent
    • Fecal-oral
    • Strain persists for decades
    • Class one carcinogen
  3. Pathogenesis
    • Adheres to gastric mucosa
    • Motility provided by flagella -> swim to less swim to less acidic pH beneath mucosa
    • Urease
    • Adhesion mediated by surface proteins
    • Cellular infiltrate -> microabcess formation
    • Vacuolating cytotoxin -> epithelial cell erosion
    • Cag -> reorganization of cytoskeleton
  4. Manifestations
    • Silent or nausea, upper abd pain
    • Gastritis, peptic ulcers -> nausea, vomiting, epigastric pain
  5. Diagnosis
    • Endoscopic examination
    • Culture
    • Potent urease activity -> one hour to detect
    • IgG, IgA for screening/evaluation
  6. Treatment
    Bismuth-salts with two antibiotics

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