Legionella

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Author:
ehamm
ID:
117650
Filename:
Legionella
Updated:
2011-11-17 23:10:23
Tags:
Legionella
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Description:
Legionella
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  1. Organism
    • Gram negative rod
    • Poor staining
    • Grow poorly on blood agar, need amino acids, ferric ions, and acidic conditions
    • Slow growing
  2. Epidemiology
    • Fresh water
    • Parasites of protozoa
    • Aerosolized water in humans
    • Large buildings i.e. factories, hotels
    • Persist despite high levels of chlorine
    • Immunocompromised persons
  3. Pathogenesis
    • Attacks lung
    • Alveoli, terminal bronchioles
    • bacteria within phagocytes
    • Mip aids entry into alveolar macrophages
    • Prevent phagosome/lysosome fusion
    • Modulates host cell traffic
    • Inhibits oxidative killing mechanism of phagocytes
  4. Immunity
    • CMI
    • Humoral immunity not as important
  5. Manifestations
    • Severe toxic pneumonia
    • Myalgia, headache, and fever
    • Dry cough
    • Chills, pleuritic chest pain, vomiting, diarrhea, confusion, delirium
    • Shock, respiratory failure
    • 15% mortaility rate
  6. Diagnosis
    • DFA
    • Culture of infected tissues
    • BAL, lung aspirates
    • Culture on special medium
    • PCR
  7. Treatment
    Antibiotics

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