Yersinia pestis

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Author:
ehamm
ID:
117764
Filename:
Yersinia pestis
Updated:
2011-11-18 18:27:51
Tags:
Yersinia pestis
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Description:
Yersinia pestis
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  1. Organism
    • Gram negative bacillus, bipolar staining
    • Enterobacteriaceae
    • Virulence plasmids
    • YOP, F1 capsular proteins - Pathogenesis
  2. Epidemiology
    • SW US
    • Rat Fleas
    • Urban - rats and humans
    • sylvatic - wild rodents and human
    • Y. Pestis multiples in foregut of flea
    • Regurgitates into bite
  3. Virulence factors
    • F1 - antiphagocytic
    • V + W Ag - antiphagocytic
    • Intracellular survival in macrophages
    • Three different virulence plasmids
  4. Manifestations
    • Site of bite: necrotic ulceration
    • Drains to LN in macrophge
    • Multiplication creates bubos; painful and tender
    • Bacteremia: DIC, septic shock, systemic spread, necrotizing hemorrhagic pneumonia
  5. Diagnosis/therapy
    • Rapid diagnosis essential
    • Gram smear of bubo aspirates
    • Culture on blood agar
    • 50-75% fatal without antibiotics
    • Pneumonic form worse
    • 10 days tetracycline

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