Brucella

Card Set Information

Author:
ehamm
ID:
117767
Filename:
Brucella
Updated:
2011-11-18 18:36:26
Tags:
Brucella
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Description:
Brucella
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  1. Organism
    • Coccobacillus
    • gram negative rod
    • Slow growing on blood agar
  2. Epidemiology
    • Disease of large mammals (cows, goats)
    • Occupations exposures for vets, farmers
    • Unpasteurized dairy products
  3. Pathogenesis
    • Multiples in non-immune macrophages
    • Localizes in RES organs
    • Facultative intracellular pathogen
    • Granulomas form in RES organs
    • Virulence factors: Smooth LPS (entry), type IV secretion system
  4. Manifestations
    • Recurrent bacteremia with fever
    • Cyclical chills and fever episodes at night, headache, arthritis, spontaneous abortion
    • Supresses host cellular response -> chronic disease
    • Insidious disease with non-specific signs
  5. Diagnosis
    • Blood culture (dangerous)
    • Serology (elisa, IgM/G)
    • Tx: doxy + rifampin

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