Rickettsia

Card Set Information

Author:
ehamm
ID:
117772
Filename:
Rickettsia
Updated:
2011-11-18 19:18:22
Tags:
Rickettsia
Folders:

Description:
Rickettsia
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user ehamm on FreezingBlue Flashcards. What would you like to do?


  1. Organism
    • obligate intracelluar bacteria
    • coccobacilli
    • giemsa stain
    • Cell wall has LPS, peptidoglycan
    • Grow in cytoplasmof eukaryotic cells
    • Endocytosis -> enter cytoplasm
    • Spread using host cytoskeleton
    • require Coenzyma A, NAD, ATP
  2. RMSF: Epidemiology
    • Ticks
    • Reservoir: rodents, dogs
    • Central, mid atlantic states
    • young kids, adults 40-65
    • Hx of tick bite
  3. RMSF: Pathogenesis
    • Vascular endothelium
    • Vasculitis in endothelial cells
    • Thrombosis, leakage of RBCs into local area -> rash, petechia
    • Vascular lesions throughout body
    • LPS mediated infection
  4. RMSF: Manifestations
    • Fever, severe headache, rash (triad) toxicity mental confusion
    • rash - 2or 3 days post infection
    • Rash - petechia
    • Appears at wrists/feet and moves to trunk
    • Rash - necrosis, gangrene
    • Incubation 2-6 days
  5. RMSF: Diagnosis
    • Serologic tests
    • Clinical signs
    • Tx: antibiotics in early illness
  6. Typhus: Epidemiology
    • Louse borne
    • war, famine, poverty
    • Relapses possible - Brills Zissner disease
  7. Typhus: Manifestations
    • Fever, headache, rash 1-2 weeks post bite
    • Maculopapular rash on trunks, spreads to limbs
    • headache, malaise, myalgia
    • Complications: mycarditis, CNS dysfunction, pneumonia
  8. Typhus: Diagnosis + Tx
    • Epidemiology, clinical signs
    • Serological tests most reliable/sensitive
    • Treat with tetracycline
  9. Q Fever: Bacteriology/epidemiology
    • Differs from other rickettsia in DNA composition
    • Zoonoses via inhalation (cattle, sheep, goats)
    • Worldwide distribution (grows well in placental tissues)
    • Survives in lysosomal vacule
    • Slaughterhouse workers
  10. Q Fever: Manifestations
    • 9-20 days post inhalation
    • Abrupt onset of fever, chills, headache, dry hacking cough
  11. Q Fever: Diagnosis/treatment
    • High or rising titers of Ab
    • Resolve spontaneously, tetracycline to shorten course

What would you like to do?

Home > Flashcards > Print Preview