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Benzodiazepine, sedative-hypnotic, anticonvulsant
Mechanism of action
Potentiates effects of inhibitory neurotransmitters. Raises seizure threshold. Induces amnesia and sedation.
Acute anxiety states, acute alcohol withdrawal (delirium tremens), muscle relaxant, seizure activity, agitation. Analgesia for medical procedures (fracture reduction, cardioversion)
Hypersensitivity, glaucoma, coma, shock, substance abuse, head injury
Rrepiratory depression, hypotension, drowsiness, ataxia, reflex tachycardia, nausea, confusion, thrombosis, and phlebitis
Incompatible with most drugs, fluids
10mg/5-mL prefilled syringes, ampules, vials, and tubex.
Dosage and Administration
- Seizure activity: adult: 5-10 mg IV every 10-15 minutes prn (5 mg over 5 min)(maximum dose, 30mg)
- Seizure activity: Pediatric: 0.2-0.5mg slowly every 2-5 minutes up to 5mg (maximum dose, 10mg/kg).
- Rectal diazepam: 0.5mg/kg via 2" rectal catheter and flush with 2-3 mL air after administration.
- Sedation for cardioversion: 5-15 mg IV over 5-10 minutes prior to cardioversion.
Duration of action
- Onset:1-5 minutes
- Peak effect: minutes
- Duration: 20-50 minutes
Pregnancy safety: Category D. Short duration of anticonvulsant effect. reduce dose 50% in elderly Pt.