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Insulin & amylin
Liver and Pancreatic β-cells
Muscle and Fat cells
>100 mg/dl blood glucose____ insulin release
< 80/90 mg/dl blood glucose _____insulin release
Insulin Secretion Stimulators
- Amino acids
- Fatty acids
- GI hormones
Insulin Secretion Inhibitors
What opposes insulin on carb metab?
What Cells Secrete Glucagon?
Pancreatic a cells
Two Types of Diabetes Insipidus:
- Central (Dec ADH)
- Nephrogenic (Dec Response to ADH)
Clin Signs of DM (7):
- Weight Loss
Most common form of Diabetes in dogs:
Type 1 DM
70-80% of diabetes in cats is of what type?
Causes of DM Type 1
- Senile Degeneration
Noninsulin Dep Daibetes=
DM Type 2
Which type of DM is due to Decreased receptors?
Insulin’s effect on: Glucose Glycogen Glycolysis Gluconeogenesis Liponeogenesis
- Glucose: Increase Uptake
- Glycogen: Inc Synthesis
- Glycolysis: Increase
- Gluconeogenesis: Decrease
Which two species have identicle insulin?
Dogs and Hogs
What two species have very similar insulin, but differs by 1 AA
Feline and Bovine
What insulin additive helps to slow down absorption and increase duration?
What insulin additive helps in crystallization?
What type of insulin is not crystallyzed?
Intermediate acting insulin=
Basic Protein that forms insulin complex-
What type of insulin is used during a hyperglycemic emergency d/t its rapid action?
Intermediate Acting Insulins include (2):
- Isophane Insulin (NPH)
- Insulin Zinc Suspension (LENTE/Vetsulin)
What brand name insulin is porcine insulin zinc suspension?
Long Acting Insulins include (2):
- Protamine Zinc Insulin (PZI)
- Insulin Glargine (Lantus)
What type of insulin is 90% Beef & 10% Pork Insulin?
Protamine Zine Insulin (PZI)
Which type of insulin is long acting but rapid release when give IV/IM?
Which type of insulin has a low pH but is neutralized upon injection and form microprecipitates that slowly release insulin?
Insulin Glargine (Lantus)
Which type of insulin is often used in cats?
PZI (Protamine Zince Insuline)
*Which insulin is preferred d/t the high rate of remissionin treated Ps?
Methods for monitoring DM Tx (3):
- Glu Curves
++Insulin => Rebound Hyperglycemia
What drugs stimulate insulin release via inhibition of ATP/K channels?
Which oral drug may have future use in cats with moderate hyperglycemia?
- (must have B Cells present, e.i. Type II diabetes, rare in dogs)
Skipped last couple of human drugs
What would you like to do?
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