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  1. First line of medication for TB?
    • Isoniazid (INH)
    • Rifampin (Rifadin)
    • Ethambutol (Myambutol)
    • Pyrazinamide (PZA)

    taken for 8 weeks
  2. What is the resistant strain called?
    why does it occur?
    • MDR-TB
    • occurs when pt receives 2 meds and discontinues ONE of the medications
  3. what are s/s of TB?
    • night sweats
    • low garde fever
    • tachycardia
    • anorexia
    • crackles
    • fatigue
    • hemoptysis
  4. Dx of TB?
    • Mantoux skin test is positive. Duration
    • Acid-fast bacillus test
    • Chest x-ray, sputum culture (3+) is most definative
  5. what type of isolation is TB?
  6. Treatment of TB lasts?
    why do pts stop too early?
    • 6-12 months
    • stop early bcuz the meds make them feel bad
  7. what is definative for nontransmissionable?
    how long on meds?
    • 3 negative sputum checks
    • > 14 days on meds
  8. what are other airborne diseases for airborne precations?
    chicken pox, shingles, meningitis
  9. DOTS...?
    Direct Observation Treatment Surveillance
  10. A Mantoux test should be administered...
    • intradermal injection to inner forearm
    • reviewed in 48 hrs for induration
  11. in order to avoid spreading Tb the pt should...
    cover mouth when coughing, family members may need to be treated also
  12. if a pt has a positive skin test result, what would next step be?
    have pt perform a definative test to determine of they have the "active" (infectious) disease
  13. what is best precaution to take when caring for this pt?
    • Use of N-95
    • high-efficiency particulate air mask (HEPA)
  14. Positive skin TB test, but not "active", what is the recommended treatment?
    prophylactic therapy with INH for 6 months
  15. what is isoniazid contraindicated in?
    hypersensativity or acute liver disease, use caution in chronic liver disease, alcoholism or renal impairment. those taking Niancin
  16. why is Pyridoxine prescribed with Isoniazid?
    reduce risk of neurotoxicity
  17. how is Isoniazid taken in regards to meals?
    1 hr before or 2 hr after meal and before antacids
  18. Rifampin inhibits the bacterial RNA synthesis but has several SE:
    hypersensitivity, fever, chills, shivers, headache, red-orange colored secretions, vision changes, hepatotoxicity, increased uric acid levels
  19. Second line drugs for TB?
    Capreomycin, ethionamide, prar-aminoslicylate sodium and cycloserine
  20. which 1st line med can be stopped after 8 weeks?
  21. which meds are continued for full 6 months?
    INH and Rifampin
  22. due to nerupathy of INH which vitamin can be given?
    Vit B
  23. meds - unique effects
    INH -
    rifampin -
    Pyrazinamide -
    Streptomycin -
    Ethambutol -
    • INH - neuropathy
    • rifampin - reddish brown fluids
    • Pyrazinamide - gout, purines monitored Streptomycin - ototoxicity, nephrotoxicity, neurotoxicity - monitor peaks/troughs Ethambutol - Visual acity red/green
Card Set
drugs and TB
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