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The causative agent of Lyme borreliosis consists of three pathogenic species
B. burgdorferi, B. afzelii, and G. garinii
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Only strain found in United States
B. burgdorferi
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The spirochete is transmitted by certain type of tick
Ixodes ricinus complex
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The larval and nyphal stages of the tick
white footed mouse
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The adult stage of th tick, the host is
white tailed deer
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The migration outward on the skin of the spirochete is called
EM erythema migrans
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The tick in the northeastern and midwestern united states
I. scapularis
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The probability of an infection after a tick bite in an endemic area is
3%
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What increases the risks that Lyme arthritis will be chronic and fail to respond to antibiotics
HLA-DR4, HLA-DR2
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No Lyme disease reported in six states?
Arkansas, colorado, hawaii, mississippi, montana, and Oklahoma.
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Adults ticks can infect but can nymphal ticks infected humans, dogs and cats
Yes.
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The first cases of spirochete-vector reported
1982
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Lyme disease accounts for ___ of all vector borne illness
95%
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Signs and symptoms of Lyme disease stage 1
Skin lesion, flu-lke symptoms, neurologic symptoms.
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Signs and symptoms of Lyme disease stage 2
abnormalities of the heart, eyes, skin and nervous system.
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Signs and symptoms of Lyme disease stage 3
Arthritis and neurological complications and cutaneous manifestations.
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The infection of Lyme disease may not become symptomatic until which stage
2 or 3.
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Arthritis occurs in about how many patients?
1/4th.
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When do symptoms of arthritis occur from Borrelia infection?
Ocurrs months to years
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Serodiagnostic test are sensitive or insensitive during first several weeks of infection.
Insensitive
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Specific IgM or IgG antibodies against B. burgdorferi are usually not detectable in patient's serum unless symptoms are present for at least
2-4 weeks.
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Lyme borreliosis is possilbe if its relative value is between
5 and 6, unklike if 4 or less.
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Most practical means of confirming infection
Assay for the detection of antibodies.
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what are some assays for detection of B. borreliosis
indirect fluorescent antibody, ELISA, PreVue B. borreliosis
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PreVue is a CLIA waived procedure intended for
first presumptive step in testing individuals for
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