Physio Mini3 Sem1

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Author:
pandachowmein
ID:
119169
Filename:
Physio Mini3 Sem1
Updated:
2011-11-27 13:31:07
Tags:
definitions muscles heart pulmonary
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Description:
Basic physio mini3 sem1
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  1. Connexon
    gap junction channels
  2. Slow response potential
    • phase 4: resting/Na+ funny channel and T-calcium channel automaticity
    • phase 0: depol - Slow type Ca2+ channel opening
    • phase 3: repol - slow L-Ca+ channel close and K+ repol channel open
  3. Fast resposne potential
    • phase 4: resting/leaky K+ channel remain depol
    • phase 0: depol - fast Na+ channel open
    • phase 1: repol - K+ channel open Na+ channel close
    • phase 2: platoe - Ca+ depol channel open to maintain depol working against K+ repol channel
    • phase 3: repol - Ca+ depol closed and K+ rapidly repols heart
  4. I funny channel
    • Na+ random channel
    • SA node, AV node, Bundle of His, Perkinji fibers
  5. T- calcium channel
    • phase 4 random automaticity channel
    • transient
    • used to open L-type calcium channels
    • SA, AV, BundleHis, Perkinki
  6. Na+ channel heart
    • used to delpo (phase 0) fast fibers
    • Atrial and ventricular muscle fibers
  7. L- Ca+ channel
    • used to depol automatic fibers (phase 0)
    • used to maintain fast fibers (phase 2)
  8. K+ channel
    • in everything, univesal depol
    • high inner ceullar concentration created repolarization (- inside) potential
  9. ATP powered relaxation
    • resequestration of Ca requires ATP
    • * SE(sarco-endoplastic)RCa
    • * PlasmaMemebraneCa
    • * Na/Ca pump
  10. Digitalis
    • Na/K pump inactivator
    • initially keeps membrane depolerized longer
    • increase Ca+ concentration in the heart muscle by blocking the Na/Ca pump that needs Na gradient to function
    • increase contractility
    • eventully the cell will die though

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