Chapter 24-25

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Author:
smota
ID:
119237
Filename:
Chapter 24-25
Updated:
2011-11-27 18:35:21
Tags:
Molecular
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Description:
Plasma Membrane receptor
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  1. cells respond to their environment
    •Each cell expresses a genetically programmed repertoire of receptors, transduction hardware and effector systems that change cellular biochemistry and behavior in response to stimuli
  2. cell receptors can respond to different environmental stimuli
    • –Chemicals-Gases-, Light–Physical force –Temperature
    • –Membrane potential
  3. 7 HELIX RECEPTORS
    •A.K.A./G protein-coupled receptors

    •Ancient:slime molds have them (but limited to eukaryotes)

    • •Numerous –4% of Caenorhabditis genome
    • –500-1000 odorant receptors in mammal

    • •Recognize a wide variety of stimuli
    • –Light, amino acids, hormones, lipids
    • –Many undetermined ligands

    •All transduce signals via trimeric GTP-binding proteins
  4. Activation 7HR
    –bindingof ligand

    • –Signaltransduction: GDP on G-trimer-GDP
    • is replaced with GTP, trimer
    • dissociates to Gα-GTP and Gβγ

    –Gα-GTPand/or Gβγ activate intracellular messengers
  5. Adaptation 7HR
    • –Gα-GTP and/or Gβγ activate second
    • messengers (e.g. diacylglycerol [DAG], protein kinases A and C),
    • which phosphorylate C-terminus of receptor

    • –Arrestin binds to phosphorylated
    • C-terminus, inactivates receptor and marks it for endocytosis (clathrin-mediated)
  6. GTP-binding proteins
    • •Large
    • family of proteins


    •Ancient: present in all living things

    • •Use GTP binding and hydrolysis
    • to switch between inactive and active states
  7. GTP Binding Protein/ Cellular Activity
    –Membrane traffic: Arf, Rab,Sar

    –Nuclear transport: Ran

    –Signal transduction: Ras

    –Regulation of cytoskeleton: Rho

    –Protein synthesis: EF

    –Protein translocation to ER: SRP
  8. Hi
    Hello

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