antimicrobials

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Author:
flucas
ID:
119512
Filename:
antimicrobials
Updated:
2011-11-28 23:10:23
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pharmacology
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Description:
pharmacology final antimicrobials mechanism of action adverse side effect
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  1. What is the mechanism of action for amoxicillin?
    • beta lactam
    • cell wall synthesis inhibitor
  2. What is the mechanism of action for cefaclor?
    • beta lactam
    • cell wall synthesis inhibitor
  3. What is the mechanism of action for ceftriaxone?
    • beta lactam
    • cell wall synthesis inhibitor
  4. What is the mechanism of action for dicloxacillin?
    • beta lactam
    • cell wall synthesis inhibitor
  5. What is the mechanism of action for meropenem?
    • beta lactam
    • cell wall synthesis inhibitor
  6. What is the mechanism of action for penicillin G?
    • beta lactam
    • cell wall synthesis inhibitor
  7. What is the mechanism of action for ticarcillin?
    • beta lactam
    • cell wall synthesis inhibitor
  8. What is the mechanism of action for vancomycin?
    • cell wall synthesis inhibitor
    • transfer step
  9. What is the mechanism of action for daptomycin?
    membrane disrupter
  10. What is the mechanism of action for isoniazid?
    • cell wall disruption
    • inhibits FAS-II mycolic acid synthesis
  11. What is the mechanism of action for moxifloxacin?
    DNA gyrase/topo IV inhibitor
  12. What is the mechanism of action for ciprofloxacin?
    DNA gyrase/topo IV inhibitor
  13. What is the mechanism of action for sulfamethoxazole?
    • folic acid pathway inhibitor
    • inhibits synthesis of dihydrofolic acid
  14. What is the mechanism of action for trimethoprim?
    • folic acid pathway inhibitor
    • inhibitor of DHFR
  15. What is the mechanism of action for amikacin?
    • irreversible protein synthesis inhibitor
    • 30S
  16. What is the mechanism of action for gentamicin?
    • irreversible protein synthesis inhibitor
    • 30S
  17. What is the mechanism of action for chloramphenicol?
    • reversible protein synthesis inhibitor
    • 50S
  18. What is the mechanism of action for clindamycin?
    • reversible protein synthesis inhibitor
    • 50S
  19. What is the mechanism of action for doxycycline?
    • reversible protein synthesis inhibitor
    • 30S
  20. What is the mechanism of action for erythromycin?
    • reversible protein synthesis inhibitor
    • 50S
  21. What is the mechanism of action for linezolid?
    • reversible protein synthesis inhibitor
    • 50S
  22. What is the mechanism of action for quinupristin/dalfopristin?
    • reversible protein synthesis inhibitor
    • 50S
  23. What is the mechanism of action for pyrazinamide?
    binds ribosomes and interferes with transcription/translation
  24. What is the mechanism of action for rifampin?
    RNA polymerase inhibitor
  25. What is the mechanism of action for metronidazole?
    forms intermediates which then destroy DNA
  26. What is the mechanism of action for clavulanic acid?
    beta-lactamase inhibitor
  27. What is the major adverse side effect of daptomycin?
    myopathy
  28. What is the major adverse side effect of isoniazid?
    • pyridoxine deficiency
    • hepatoxicity
  29. What is the major adverse side effect of moxifloxacin?
    potential tendon rupture
  30. What is the major adverse side effect of ciprofloxacin?
    potential tendon rupture
  31. What is the major adverse side effect of amikacin?
    nephro/oto/neuro toxicity
  32. What is the major adverse side effect of gentamicin?
    nephro/oto/neuro toxicity
  33. What is the major adverse side effect of chloramphenicol?
    bone marrow depression
  34. What is the major adverse side effect of clindamycin?
    superinfection
  35. What is the major adverse side effect of doxycycline?
    • incorporates into teeth/bones
    • photosensitivity
  36. What is the major adverse side effect of erythromycin?
    • epigastric distress
    • cholestatic hepatitis
  37. What is the major adverse side effect of linezolid?
    thrombocytopenia
  38. What is the major adverse side effect of quinupristin/dalfopristin?
    • venous inflammation
    • arthralgia
  39. What is the major adverse side effect of pyrazinamide?
    polyarthralgia
  40. What is the major adverse side effect of metronidazole?
    • headache
    • peripheral neuropathy
    • alcohol sensitivity
  41. What is the mechanism of action for amphotericin B?
    • causes membrane permeability pores
    • anti-fungal
  42. What is the mechanism of action for caspofungin?
    • inhibits beta-glucan synthase
    • anti-fungal
  43. What is the mechanism of action for fluconazole?
    • inhibits ergosterol biosynthesis
    • anti-fungal
  44. What is the mechanism of action for flucytosine?
    • forms fluorouracil in cell --> inhibits thymidylate synthetase and DNA synthesis
    • anti-fungal
  45. What is the mechanism of action for itraconazole?
    • inhibits ergosterol biosynthesis
    • anti-fungal
  46. What is the major adverse side effect of amphotericin B?
    • nephrotoxicity
    • fever
    • chills
  47. What is the major adverse side effect of caspofungin?
    • headache
    • GI distress
    • histamine release
  48. What is the major adverse side effect of flucytosine?
    (rare) bone marrow depression
  49. What is the mechanism of action for acyclovir?
    • blocks viral DNA polymerase by forming guanosine-analogue complex via viral thymidine kinase
    • anti-viral
  50. What is the major adverse side effect of efavirenz?
    • CNS toxicity
    • skin rashes
  51. What is the mechanism of action for efavirenz?
    • non-nucleotide reverse transriptase inhibitor
    • anti-viral
  52. What is the mechanism of action for enfuvirtide?
    • entry inhibitor
    • anti-viral
  53. What is the mechanism of action for fosamprenavir/amprenavir?
    • HIV protease inhibitor
    • anti-viral
  54. What is the mechanism of action for foscarnet?
    • blocks viral DNA synthesis
    • anti-viral
  55. What is the mechanism of action for ganciclovir?
    • blocks viral DNA synthesis
    • anti-viral
  56. What is the mechanism of action for interferon?
    • regulates the Jak/STAT pathway
    • anti-viral
  57. What is the mechanism of action for lamivudine?
    • reverse transcriptase inhibitor
    • anti-viral
  58. What is the mechanism of action for oseltamivir?
    • neurominidase inhibitor
    • anti-viral
  59. What is the mechanism of action for raltegravir?
    • inhibits HIV integrase
    • anti-viral
  60. What is the mechanism of action for ritonavir?
    • HIV protease inhibitor
    • inhibits CYP3A4
    • anti-viral
  61. What is the mechanism of action for telaprevir?
    • inhibits Hepatitis C protease
    • anti-viral
  62. What is the mechanism of action for zidovudine (AZT)?
    • reverse transcriptase inhibitor
    • anti-viral
  63. What is the major adverse side effect of fosamprenavir/amprenavir?
    lipodystrophy
  64. What is the major adverse side effect of foscarnet?
    nephrotoxicity
  65. What is the major adverse side effect of ganciclovir?
    bone marrow toxicity
  66. What is the major adverse side effect of interferon?
    • bone marrow depression
    • flu-like symptoms
  67. What is the major adverse side effect of oseltamivir?
    no major limiting toxicity
  68. What is the major adverse side effect of ritonavir?
    inhibits CYP3A4
  69. What is the major adverse side effect of zidovudine (AZT)?
    bone marrow depression

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