Fibric-acid Derivatives

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Author:
mpgcuenca
ID:
119680
Filename:
Fibric-acid Derivatives
Updated:
2011-11-29 20:43:44
Tags:
Anti Hyperlipidemics Drugs
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Fibric-acid Derivatives
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  1. Fibric-acid Derivatives
    • Gemfibrozil (Lopid)
    • Clofibrate (Tricor)
    • Fenofibrate (Lofibra)
  2. 1. Indication
    2. Effect
    • 1. Treat severe hypertriglyceridemia and chylomicronemia syndrome.
    • 2. Decrease triglyceride levels by 50%
    • Increase HDL by 15%
    • LDLs may stay the same
  3. 1. MoA
    2. RoA
    • 1. Exact MoA unclear. Bind to peroxisome proliferator-activated receptors (PPARs) that regulate gene transcription.
    • 2. PO
  4. 1. Absorption
    2. Distribution
    3. Metabolism
    4. Elimination
    • 1. Rapid w/ meals, slow w/o meals
    • 2. Peak [plasma] 1-4 hrs
    • 3. 1/2 life of gemfibrozil is 1.1 hours and fenofibrate is 20 hrs.
    • 4. Urine as glucuronide conjugates (contraindicated in pts w/ renal failure)
  5. 1. Common SEs
    2. Unique SEs
    • 1. GI, less frequent rash, urticaria, hair loss, myalgias, fatigue, headache, impotence, anemia (can potentiate anticoags. s.a. Warfarin).
    • 2. Myopathy syndrome if gemfibrozil taken w/ statins
  6. Clinical Use
    • Fixed dose
    • Care if given with anticoags.
    • Care for myopathy if given w/ statins.

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