Card Set Information
Anti Hyperlipidemic Drugs
Bile-acid Sequestrant Drugs
Indication & Role
Lowering LDLs 12%-25%
HDLs increase 4%-5%
Reduction in cardiovascular events with the use of cholestyramine.
Highly positively charged and bind the negatively charged bile acids & their excretion in the stool.
Decrease in pool of bile acids leads to hepatic bile acid synthesis and hepatic cholesterol content declines.
This causes an increase in hepatic LDL receptors, which lowers LDL levels.
This is partially offset with up-regulation of HMG-CoA reductase.
There is also an increase in hepatic triglyceride synthesis.
Cholestyramine as powder
Colestipol as powder or tablets (sluree)
Colesevelam as solid tablet
(Poor compliance due to consistency & bloating SEs)
Absorption & Elimination
Entirely eliminated in feces
Contraindicated in pre-existing hypertriglyceridemia
Interfere w/ absorption of thiazides, furosemide, propanolol, L-thyroxine, digoxin, warfarin, and some statins
Pts that don't tolerate Statins
Usage limited due to unpleasant GI SEs