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Ezetimibe (Zetia)
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Indication & Role
Lowers LDLs 15-20% as monotherapy
In combo w/ high-dose simvastatin LDLs lowered 60%
MoA
Inhibits jejunal transport of cholesterol may cause reflexive cholesterol synthesis increase.
If taken with simvastatin it could lower LDLs
RoA
Oral tab
Combo w/ simvastatin in various strengths (Vytorin)
1. Absorption
2. Elimination
1. Water insoluble, absorbed in the intestine and into enterohepatic recirculation
2. 70% excreted in feces, 10% in urine
Common SEs
Rare allergic rxns.
Clinical Use
Used in combo with a statin.
Rarely used as monotherapy
Contraindicated w/ bile-acid sequestrants
Author
mpgcuenca
ID
119746
Card Set
Ezetimibe (Zetia)
Description
Ezetimibe (Zetia)
Updated
11/30/2011, 5:19:49 AM
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