Ezetimibe (Zetia)

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Author:
mpgcuenca
ID:
119746
Filename:
Ezetimibe (Zetia)
Updated:
2011-11-30 00:19:49
Tags:
Anti hyperlipidemic Drugs
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Description:
Ezetimibe (Zetia)
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  1. Indication & Role
    • Lowers LDLs 15-20% as monotherapy
    • In combo w/ high-dose simvastatin LDLs lowered 60%
  2. MoA
    • Inhibits jejunal transport of cholesterol may cause reflexive cholesterol synthesis increase.
    • If taken with simvastatin it could lower LDLs
  3. RoA
    • Oral tab
    • Combo w/ simvastatin in various strengths (Vytorin)
  4. 1. Absorption
    2. Elimination
    • 1. Water insoluble, absorbed in the intestine and into enterohepatic recirculation
    • 2. 70% excreted in feces, 10% in urine
  5. Common SEs
    Rare allergic rxns.
  6. Clinical Use
    • Used in combo with a statin.
    • Rarely used as monotherapy
    • Contraindicated w/ bile-acid sequestrants

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