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Indication & Role
Lowers LDLs 15-20% as monotherapy
In combo w/ high-dose simvastatin LDLs lowered 60%
Inhibits jejunal transport of cholesterol may cause reflexive cholesterol synthesis increase.
If taken with simvastatin it could lower LDLs
Combo w/ simvastatin in various strengths (Vytorin)
1. Water insoluble, absorbed in the intestine and into enterohepatic recirculation
2. 70% excreted in feces, 10% in urine
Rare allergic rxns.
Used in combo with a statin.
Rarely used as monotherapy
Contraindicated w/ bile-acid sequestrants