SABA's

Card Set Information

Author:
mpgcuenca
ID:
119766
Filename:
SABA's
Updated:
2011-11-30 02:16:15
Tags:
Asthma COPD Drugs
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Description:
Short-acting beta2 agonists
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  1. SABA's
    • Albuterol (Proventil, Ventolin, ProAir)
    • Pirbuterol (Maxair)
    • Metaproterenol (Alupent)
    • Levalbuterol (Xopenex)
  2. MoA
    • Beta 2 receptor stimulation, attaches to a G protein-linked receptor, stimulates adenylyl cyclase, increases
    • cAMP.
    • Induces the Na+-K+ ATPase pump,
    • Stimulates insulin release from the pancreas
    • Stimulates glycogenolysis in liver and muscle raising glucose.
  3. Effects
    • Bronchial smooth muscle relaxation
    • Inhibition of inflammatory mediator release (inhibits mast cell activation and degranulation, prevents increased vascular permeability)
    • Increased mucociliary clearance
    • Reduction in extracellular potassium
  4. Indications
    • Intermittent asthma
    • Exercise-induced bronchospasm
    • Rescue inhaler in acute exacerbations
    • Hyperkalemia- can lower K+ by 0.5 to 1.5meq
  5. SEs 1
    • Tremor
    • Tachycardia
    • Palpitations
    • Angina
    • Worse bronchospasm
    • Hypokalemia
    • Tachyphylaxis if used too often
    • Hypersn rxns
    • SNS blockers may diminish effect
    • TCAs/MAOIs may ↑ it
  6. SEs 2
    Oral tablets & syrup have ↑ side effects due to systemic absorption & long duration of action

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