LABA's

Card Set Information

Author:
mpgcuenca
ID:
119769
Filename:
LABA's
Updated:
2011-11-30 02:42:57
Tags:
Asthma COPD
Folders:

Description:
Long-acting beta2 agonists
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  1. LABA's
    • Salmeterol
    • Formoterol
    • Arformoterol
  2. MoA
    • Beta 2 receptor stimulation
    • Attaches to a G protein-linked receptor
    • Stimulates adenylyl cyclase increasing cAMP
    • Also stimulates Na+-K+ ATPase pump and insulin release
  3. Use
    • Exercise-induced bronchospasm
    • Asthma control
    • Do not use alone
    • No tachyphylaxis
  4. Effects
    • Similar to SABA’s but minimal anti-inflammatory effects
    • or mucociliary clearance.
    • Less useful for K+ movement due to slower onset of action.
  5. Major SEs
    • Headaches
    • Musculoskeletal pain
    • Carries a “black box” warning for increased asthma deaths, particularly among
    • African-American population
    • Should not be used for acute symptoms
    • Should not be instituted in patients with significantly worsening asthma or acute exacerbations, due to reports of severe respiratory events – deaths
  6. Contraindication/Drug interactions
    • Contraindications – as above.
    • Drug interactions – beta blockers may reduce effect.

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