Card Set Information
Long-acting beta2 agonists
Beta 2 receptor stimulation
Attaches to a G protein-linked receptor
Stimulates adenylyl cyclase increasing cAMP
Also stimulates Na+-K+ ATPase pump and insulin release
Do not use alone
Similar to SABA’s but minimal anti-inflammatory effects
or mucociliary clearance.
Less useful for K+ movement due to slower onset of action.
Carries a “black box” warning for increased asthma deaths, particularly among
Should not be used for acute symptoms
Should not be instituted in patients with significantly worsening asthma or acute exacerbations, due to reports of severe respiratory events – deaths
Contraindications – as above.
Drug interactions – beta blockers may reduce effect.