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- IgG monoclonal antibody which inhibits IgE binding to the high-affinity IgE receptor on mast cells and basophils.
- The activation and release of mediators in the allergic response are decreased.
Asthma refractory to standard therapy
- “Box warning” for anaphylaxis occurring 2-24hrs after administration
- Only given in healthcare setting by trained personnel with supplies available to treat anaphylaxis
- Patients also are required to have injectable epinephrine available at home and instructed on its use
- Monitor patients who are at risk for helminth infections may exacerbate
- Acute bronchospasm
- Status asthmaticus
- None documented at current time
- Note – has not been documented to be cost effective treatment. Optimal use and indication still not clearly