Methylxanthines

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  1. Methylxanthine Drugs
    Theophylline (Uniphyl, Theochron)
  2. MoA
    • Bronchodilator & anti-inflammatory properties due to adenosine receptor antagonism & phosphodiesterase inhibition (↑ cAMP & cGMP), especially PDE4
    • Also have anti-inflammatory effects by augmenting Histone deacetylase-2
  3. Dispensation
    • Oral & IV
    • Narrow therapeutic window
  4. SEs
    • Tachycardia
    • Headache
    • Insomnia
    • Nausea
    • Vomiting
    • Cardiac arrythmias
    • Seizures (resistant to anticonvulsants)
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119779
Card Set
Methylxanthines
Description
Methylxanthines
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