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Theophylline (Uniphyl, Theochron)
- Bronchodilator & anti-inflammatory properties due to adenosine receptor antagonism & phosphodiesterase inhibition (↑ cAMP & cGMP), especially PDE4
- Also have anti-inflammatory effects by augmenting Histone deacetylase-2
- Oral & IV
- Narrow therapeutic window
- Cardiac arrythmias
- Seizures (resistant to anticonvulsants)
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