Drug Discovery and Development 2

Gleevec is a new drug used in the treatment of chronic myelogenous lukemia (CML). Gleevec binds to the Abl protein and inhibits its activity. Gleevec also shows promise in the treatment of gastrointestinal stromal tumors (GSTs), but has no effect on lung cancer. Which statement is the most consistent with the above information?

Cancer is more common in older people because

How did luck play a role in the discovery of the "mustard liquid" chemotherapy drugs?

The discovery of the mustard liquid drugs would be best described as

Legislation passed after a legally marketed drug killed 107 people, most of whom were children

The effective dose 50% (ED50) is most closely asociated with a drug's:

Which of the following metabolically active tissues is the principle organ for drug metabolism?

Which of the following statements is not true about cytochrom P450 enzymes?

Which of the following is usually the "goal" of drug metabolism.

Which of the following do patent examiners not consider when evaluating patentability of a new product or process?

Pharmacokinetics considers:

Most drugs and metabolits are excreted in:

Who is David Franklin?

Pharmacoeconomics is used to estimate and compare consts and health-related outcomes for drugs, but this information is typically not considered by the FDA when reviewing a new drug application. T/F

Pharmacodynamics considers

A drug that binds to a cell receptor and causes a direct response is called an

What the body does to a drug is called

The most common factor associated with variation in an invididuals's response to a drug is

How does acetaminophen (tylenol) cause toxicity in overdose

In a qui tam action, the citizen who files the law suit is called a/an:

HIV is the virus that causes AIDS. In the mid-1990s, researchers discovered an enzyme in HIV called a protease. Once the enzyme's structure was known, researchers began looking for drugs that would fit into the active site and block it. If this strategy for stopping HIV infections were successful, it would be an example of?

During the early years of cancer research, there were two schools of thought regarding the causes of cancer: 1) that cancer was caused entirely by environmental factors and 2) that cancer was caused by genetic factors. Which is correct?

Pharmacodynamics is defined as

NSAIDs work by

Which of the following laws established that drugs should be accurately labeled with contents and dosage

Which federal law would a pharmaceutical company be accused of violating if their television advertisement was misleading?

Which pharmacoeconomic analysis has the advantage of being the simplest to conduct because the outcomes are ssumed to be equivalent?

Informed consent in clinical trials is important because

In the U.S. obesity has become a major health policy issue over the past twenty years becasue

A law suit brought by a citizen against another citizen or corporation who has defrauded the government is called

Why are some prescription drugs not available as less expensive generic drugs?

Which of the following best describes a "fiduciary relationship" such as that between a physician and patient?

For intravenour dosages, what is the bioavailability assumed to be?

The relationship between the amount of a drug taken and the intensity or type of the resulting effect is called the

During which phase in the development of pharmaceutical drugs is the drug tested on healthy human volunteers to test for toxicity.

Metastatsis, in the context of Cancer, is the process of

Which of the following is the process of transporting a drug from its administration site to its site of action.

Opiates such as morphine and codeine both contain molecules that are similar to endorphins, the body's "natural painkillers". Opiates like these bind to receptor sites that are keyed to endorphins and trigger similar pain reducing responses. Given these characteristics, both morphine and codeinie would be classified as,

Which of the following statmetns about pharmaceutical sales is true?

Pharmaceutical companies historically marketed only to doctors. More recently, they have spent millions of dollars to advertise prescription drugs directly to consumers. Which of the following is not a consequence of DTC pharmeceutical advertising.

Lisa Simpson identified a drug candidate by testing thousands of compounds in a "chemical library" for activity against the isolated protein target. This approach to drug discovery would best be classified as

A phase II trial is mainly used to determine

Some components in food inhibit one of the major CYP enzymes that metabolize many drugs. This inhibition would result in the following outcome:

The method of comparing the cosrts and benefits of health care interventions in which benefits are quantified as length and quality of life is:

Probably the most important reason for obesity today in North America is:

If a company has a patent on a drug that treats a particular disease

With prescription drugs there is a trade-off between

When the molecular structures of COX-1 and COX-2 were elucidated, compounds with specific antagonist activity at COX02 were developed. Celecovib and rofecoxib, the first specific COX-2 inhibitors, were developed and tested in animal models. They were found to decrease the inflammatory response in animals without causing adverse effects. The trials of COX-2 inhibitors in animals are examples of

Which of the following are not typical of a phase I clinical trial

In the late 1980's, the United States experienced an epidemic of heroin abusers dying from accidental overdose of a short-acting synthetic opiod agonist, 3-methyl fentanyl, known on the street as China White. This compound was estimated to have 6000 times the potency of morphine. Pharmaceutical fentanyl has 100 times the potency of morphine. Which of the following curves are consistent with this information?