What happens to solar radiation with increase of altitude?
Solar radiation increases with altitude
What happens to alveolar pressure with hypoxia?
It rapidly decreases then stays constant during hypoxia
What happens to minute ventilation during hypoxia?
It steadly increases over time
What happens to the pressure of oxygen and carbon dioxide during hypoxia?
Increases pressure of oxygen
Decreases pressure of carbon dioxide
What do glomus cells in carotid bodies do?
When stimulated they increase ventilation
What stimulates glomus cells?
With hyperventilation it increases pO2 and decreases pCO2 which are opposite forces what does the body do to sustain hyperventilation?
CO2 + H2O --> H+ + HCO3
HCO3 is taken out of CSF to reduce pH
Glomus cells become more sensitive to pO2
Kidneys excrete more HCO3 lowering plasma pH
During hypoxia what kind of cardiovascular acclimatization happen?
increase cardiac output
Hypoxia stimulates HIF1A, which stimulates EPOgene, which stimulates erythopetin (kidneys), which increases RBC
Affects Hb-O2 dissociation
What are some problems with increase RBC?
Increases the viscosity, can lead to heart failure
Risk of infection
What happens to Hb-O2 dissociation during hypoxia cardiovascular acclimization?
Increases the p50, which therefore causes a shift in the Hb-O2 dissociation curve to the right, which has the same binding affinity of O2 at the lungs but decreases the binding affinity of O2 at the tissues making it easier for the tissues to obtain the O2