Pulmonary HTN

Card Set Information

Author:
mpgcuenca
ID:
119938
Filename:
Pulmonary HTN
Updated:
2011-11-30 20:55:24
Tags:
Asthma COPD
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Description:
Pulmonary HTN
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  1. Pulmonary HTN
    • Calcium channel blockers
    • Epoprostenol (Flolan)
    • Treprostinil (Remodulin, Tyvaso)
    • Iloprost (Ventavis)
    • Bosentan (Tracleer)
    • Ambrisentan (Letairis)
    • Sildenafil (Revatio)
    • Tadalafil (Cialis)
  2. General Therapy for PAH & PH
    • 1. Diuretics
    • 2. Oxygen
    • 3. Anti-coagulation, however, really only studied in Group 1 patients
    • 4. Digoxin
    • 5. Exercise
  3. MoA
    • Epoprostenol
    • Potent vasodilator & platelet inhibitor
    • Acts locally on the endothelium

    • Treprostinil
    • A prostanoid
    • Acts as a potent pulmonary and systemic vasodilator and platelet aggregation inhibitor

    • Iloprost
    • Prostaglandin
    • vasodilator, suppresses vascular smooth muscle proliferation
    • inhibits platelet aggregation
    • Very expensive, ~$3000/month

    • Bosentan
    • Nonselective endothelin receptor antagonist
    • Blocks endothelin receptors on vascular
    • endothelium and smooth muscle

    • Ambrisentan
    • A selective type A endothelin-1 receptor antagonist

    • Sildenafil
    • A cyclic GMP phosphodiesterase type 5 inhibitor
    • Prolongs the vasodilatory effect of nitric oxide

    • Tadalafil
    • Phosphodiesterase – 5 enzyme inhibitor
    • Similar to sildenafil

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