Card Set Information
First Gen. Antihistamine Drugs
Brompheniramine (Lodrane, LoHist,Bidhist)
Third line therapy for allergic rhinitis
Not as effective as INGC
Three categories of effect;
May shift balance from H1 receptor form to the inactive H1 receptor form thereby down regulating the H1 receptor activity
Blocks increased vascular permeability, pruritis, bronchial smooth muscle constriction, and can cause mucosal drying
May also effect eosinophil survival
May cause CNS depression, use caution with driving.
Anticholinergic effects. Dry mouth, urinary retention, possible worsening of narrow angle glaucoma, confusion.
Acetylcholinesterase inhibitors decrease effect.
Anticholinergics increase side effects.
Additive effect with central nervous system depressants.
May increase the arrhythmogenic effect of phenothiazines.
FDA has now issued a warning that use of these medications in children under 2yrs of age, has an increased mortality. “blackbox warning”.