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Ipratropium bromide (Atrovent nasal spray)
- Second or third line treatment for allergic rhinitis.
- Useful for vasomotor rhinitis.
- Blocks the action of acetylcholine at parasympathetic sites in the mucosa
- Competes with acetylcholine for M3 receptor sites(anticholinergic, major), and binds nonselectively to M2 receptor sites(cholinergic, minor)
Onset of action
Rapid, several minutes
- Severe nasal drying
Hypersensitivity to the drug
Anticholinergics increase the effects.
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