Indirect Sympathomimetics

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Author:
jaguavai
ID:
120058
Filename:
Indirect Sympathomimetics
Updated:
2011-12-01 10:54:55
Tags:
Pharm 420
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Description:
Indirect Sympathomimetics
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  1. Indirect sympathomimetics (8)
    • Amphetamine
    • Tyramine
    • Methylphenidate (Ritalin)
    • Dextgroamphetamine
    • Atomoxetine (Straterra)
    • Modafinil (Provigil)
    • Phentermine
    • Lisdexamfetamine
  2. Amphetamine Therapeutic Use (3)
    • ADHD
    • Nacrolepsy
    • Obesity (short acting)
  3. Amphetamine MOA (2)
    • Inhibits reuptake of DA and NE, more DA and NE available for transmission in prefrontal cortex
    • Reverses action of NET.
  4. Amphetamines and noradrenergic pathway
    Increases neurotransmission originating in locus coeruleus
  5. Amphetamines in dopaminergic pathway
    Enhances transmission in the ventral tegmental area, projecting to nucleuc accumbens (pleasure center)
  6. Amphetamine adverse effects (4)
    • Restlessness
    • Insomnia
    • talkativeness
    • Headache
  7. Amphetamine drug interactions (3)
    • Acidifying agents - increase urinary excretion
    • Alkalinizing agents - potentiate their effect
    • Tricyclic antidepressans - increase in [AMP] in brain, increased CV effects

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