Antimuscarinics, Atropine etc.

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Author:
jaguavai
ID:
120083
Filename:
Antimuscarinics, Atropine etc.
Updated:
2011-12-01 13:30:37
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Pharm 420
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Antimuscarinics, Atropine
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  1. Atropine major pharmacological effects (6)
    • Increased HR
    • Decreased secretion of exocrine glands
    • Smooth muscle relaxation
    • Mydriasis
    • Cycloplegia (prevents distant vision)
    • Dose-related CNS effects
  2. Atropine blocks ?
    All muscarinic receptors, but dependent on dose
  3. Atropine pharmacokinetics
    • Rapid oral absorbtion
    • Tertiary amine - penetrates BBB
  4. Atropine adverse effects (9)
    • Xerostomia (block M3) dry mouth/eyes
    • Anhidrosis (block M3), hyperthermia, heat stroke
    • Urinary retention
    • Constipation
    • Makes GERD worse
    • Tachycardia (block M2)
    • Bradycardia
    • Blurred vision
  5. Atropine drug interactions (3)
    • Additive effects
    • Antihistamines
    • May alter absorbtion of other drugs
  6. Tolterodine use
    Overactive bladder
  7. Dicyclomine uses
    Relieve muscle spasms of GI tract
  8. Oxybutynin use (1)
    Overactive bladder
  9. Benztropin use (1)
    Alzheimer's
  10. Glycopyrrolate uses (4)
    • Reduces salivary glands
    • Vagal-induced bradycardia during anesthesia
    • Adjunct for PUD
    • Reverse n euromuscular blockade during anesthesia
    • Abnormal drooling in kids with cerepral palsy
  11. Tiotropium use (1)
    Bronchospasm associated with COPD

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