Endocrine drugs

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Author:
ldewanz
ID:
120358
Filename:
Endocrine drugs
Updated:
2011-12-03 12:10:06
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Endocrine drugs
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Endocrine drugs
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  1. Aspart
    • Insulin/analog
    • Rapid acting/prevent self association
  2. Detemir
    • Insulin/analog
    • Long Acting/self aggregation/bind to albumin
  3. Glargine
    • Insulin/analog
    • Long Acting/soluable at acid pH
  4. Glulisine
    • Insulin/analog
    • Rapid acting/prevent self association
  5. Lispro
    • Insulin/analog
    • Rapid acting/prevent self association
  6. NPH
    • Insulin/analog
    • Intermediate acting
  7. Crystaline insulin
    • Insulin/analog
    • Short acting
  8. Exenatide
    • Incretin-like drug/Type II only
    • MOA: stim beta-cells/inhib alpha-cells (dec glucagon/ inc insulin)
    • SubQ
  9. Sitagliptin
    • Incretin-like drug/Type II only
    • MOA: stim beta-cells/inhib alpha-cells (dec glucagon/ inc insulin)
    • Inhib Enz that breaksdown incretin
    • Oral
  10. Pramlintide
    • Amylin Analog/Type I and II use
    • MOA: inhib glucagon secretion/hormone made in alpha-cells/CNS-mediated anorectic
    • SubQ
  11. Chlorpropamide
    • Sulfonylurea/1st gen
    • MOA: insulin secretagogues/ blk K+ channel on Beta-islet/inc intracell Ca++/Inc insulin
    • HYPOglycemia
    • SE: allergies (S-J syndrome)/weight gain
  12. Glipizide
    • Sulfonylurea/2nd gen
    • MOA: insulin secretagogues/ blk K+ channel on Beta-islet/inc intracell Ca++/Inc insulin
    • HYPOglycemia
    • SE: allergies (S-J syndrome)/weight gain
  13. Glyburide
    • Sulfonylurea/2nd gen
    • MOA: insulin secretagogues/ blk K+ channel on Beta-islet/inc intracell Ca++/Inc insulin
    • HYPOglycemia
    • SE: allergies (S-J syndrome)/weight gain
  14. Glimepiride
    • Sulfonylurea/2nd gen
    • MOA: insulin secretagogues/ blk K+ channel on Beta-islet/inc intracell Ca++/Inc insulin
    • HYPOglycemia
    • SE: allergies (S-J syndrome)/weight gain
  15. Tolbutamide
    • Sulfonylurea/1st gen
    • MOA: insulin secretagogues/ blk K+ channel on Beta-islet/inc intracell Ca++/Inc insulin
    • HYPOglycemia
    • SE: allergies (S-J syndrome)/weight gain
  16. Repaglinide
    • Meglitinide
    • MOA: same as sufaureas/more potent/insulin secretion
    • SE: HYPOglycemia/weight gain
  17. Nateglinide
    • phenylalanine analog
    • MOA: same as sulfaurea/insulin secretion/faster action/ shorter duration
    • Less HYPOglycemia
    • Safer for renal damage
  18. Metformin
    • Biguanide/Type II DM (first line)
    • Oral
    • No Hypoglycemia
    • MOA: dec gluconeogenesis in liver by activate AMP-protein kinase
    • SE: lactic acidosis/GI/NO hypoglycemia
  19. Rosiglitazone
    • Thiazolidinedione
    • MOA: PPAR gamma-agonists/inc insulin sensitivity
    • NO HYPOglycemia
    • SE: hepatotox/weight gain/heart attack/stroke
  20. Pioglitazone
    • Thiazolidinedione
    • MOA: PPAR gamma-agonists/inc insulin sensitivity
    • NO HYPOglycemia
    • SE: hepatotox/weight gain/bladder CA
  21. Acarbose
    • Alpha-glucosidase inhibitor
    • MOA: inhib breakdown of glucose (intestinal brush boarder)/dec monosaccharide breakdown
    • SE: (bacteria use sugar) flatulance/diarrhea/abdo pain/ NO weight gain
  22. Miglitol
    • Alpha-glucosidase inhibitor
    • MOA: inhib breakdown of glucose (intestinal brush boarder)/dec monosaccharide breakdown/dec carb absorb
    • SE: (bacteria use sugar) flatulance/diarrhea/abdo pain/ NO weight gain
  23. Thyroxine
    • Thyroid hormone
    • MOA: synthetic T4
    • SE: thyrotoxicosis/inc CV events
    • Preg women require more hormone
  24. Triiodothyronine
    • Thyroid hormone
    • MOA: oral T3
    • SE: thyrotoxicosis/inc CV events
    • More freq/better oral/$$$
    • Preg women require more hormone
  25. T4+T3
    Thyroid hormone
  26. Propylthiouracil (PTU)
    • Thioamide/Thioureylene
    • MOA: inhib (by thyroid peroxidase)oxidation/iodination/ coupling/dec periferal convert of T4
    • SE: rash/agranulocytosis(dec neutrophils/inc infection)/ hypothyroid/thyroid storm/teratogenic
    • Slow onset
  27. Methimazole
    • Thioamide/Thioureylene
    • MOA: inhib (by thyroid peroxidase)oxidation/iodination/ coupling/dec periferal convert of T4
    • SE: rash/agranulocytosis(dec neutrophils/inc infection)/ hypothyroid/thyroid storm
    • Slow onset
  28. Potassium Iodide
    • MOA: initial inhib (synthesis/release) of T3/T4 secretion (transient)
    • Nuclear protectant
    • Oral/combo therapy
    • SE: rash/allergy/swollen salivary glands
    • Give >6mg/day//fast onset
  29. Radioactive iodine I-131
    • dx and tx
    • NOT preg or nursing mothers
    • SE: delayed hypothyroidism
  30. Propranolol
    • used in treat of HYPERthyroidism
    • alleviate inc CV activity
  31. Cortisol
    • Glucocorticoid
    • Use: Replacement tx/emergencies
    • SE: Hyperglc/inc TG/osteoporosis/inc infection/euphoria/ cataracts/dec HPA axis/inc appetite
  32. Dexamethasone
    • Glucocorticoid
    • Use: anti-imflammatory/immunosuppressive/ water retension undesirable
    • SE: Hyperglc/inc TG/osteoporosis/inc infection/euphoria/ cataracts/dec HPA axis/inc appetite
  33. Prednisolone
    • Glucocorticoid
    • Use: anti-inflammatory/immunosuppressive
    • SE: Hyperglc/inc TG/osteoporosis/inc infection/euphoria/ cataracts/dec HPA axis/inc appetite
  34. Fludrocortisone
    • Mineralocorticoid
    • Use: adreanal insufficiency
    • SE: fluid and electrolyte abnormalities/HTN
  35. Spironolactone
    • Mineralocorticoid antagonist/androgen antagonist
    • Use: primary aldosteronism (adenoma/hyperplastic adrenal/malignant tumor)
  36. Eplerenone
    • Mineralocorticoid antagonist
    • Use: primary aldosteronism (adenoma/hyperplastic adrenal/malignant tumor)
  37. Aminoglutethimide
    • synthesis inhibitor/anti-GC
    • MOA: inhib cholesterol to pregnenolone (whole pathway)
    • Use: Cushing's
  38. Metyrapone
    • synthesis inhibitor/anti-GC
    • MOA: inhib 11-deoxy conversion of GC
    • Use: Cushing's
  39. Ketoconazole
    • synthesis inhibitor/anti-GC
    • MOA: anti-fungal/multi-step inhib
    • Use: Cushing's
  40. Estradiol
    Estrogen
  41. Ethinyl estradiol
    • Estrogen
    • MOA: inhib ovulation/suppress HPG axis
    • SE: stroke/DVT/bone protection/weight gain/dec glucose tol/inc HDL
    • C/I: smokers over 35
  42. Estrone sulfate
    • Estrogen
    • MOA: inhib ovulation/suppress HPG axis
    • SE: stroke/DVT/bone protection/weight gain/dec glucose tol/inc HDL
    • C/I: smokers over 35
  43. Diethylstilbestrol
    • Estrogen
    • MOA: inhib ovulation/suppress HPG axis
    • SE: stroke/DVT/bone protection/weight gain/dec glucose tol/inc HDL
    • C/I: smokers over 35
  44. Tamoxifen
    • SERM
    • Use: Antag in breast only/relieve postmen/osteoporosis/ dec breast CA
  45. Raloxifen
    • SERM
    • Use: Antag in breast and uterus/relieve postmen/ osteoporosis/dec breast CA/less thromboembolic
  46. Clomiphene
    • Estrogen receptor antagonist
    • Use: induce ovulation/antag inhib on pituitary and hypothalamus
  47. Fulvestrant
    • Estrogen receptor antagonist
    • Use: induce ovulation/antag inhib on pituitary and hypothalamus
  48. Anastrozole
    • Aromatase inhibitor
    • MOA: inhib androgen to estradiol
    • SE: menopause
  49. Exemestane
    • Aromatase inhibitor
    • MOA: inhib androgen to estradiol
    • SE: menopause
  50. Drospirenone
    • Progestin
    • inc activity as MC and androgen antagonist
    • Use: endometrial development/dec mucous
  51. Progesterone
    • Progestin
    • Use: endometrial development/dec mucous
  52. Medroxyprogesterone acetate
    • Progestin/IM/3 mon shot
    • MOA: dec cervical mucous
    • SE: HA/abnormal bleeding
  53. Norethindrone
    • Progestin only contraception
    • MOA: dec cervical mucous
    • SE: HA/abnormal bleeding
    • Oral/IUD
  54. Norgestrel
    • Progestin only
    • MOA: dec cervical mucous
    • SE: HA/abnormal bleeding
    • Oral/IUD
  55. RU 486
    • Progestin receptor antagonist
    • Mifepristone
    • MOA: stimulate menstration/inhib HPG axis
    • Use: abortion (combo w/PGE analog)
    • SE: GC antagonist
  56. FSH
    • Gonadotropin
    • Use: induce follicular growth
  57. CG
    • Gonadotropin
    • Use: induce ovulation
  58. Gonadorelin
    • GnRH/analog
    • Short acting
    • Pulsitile
    • MOA: inc gonadotropins/inc fertility
  59. Luprolide
    • GnRH/analog
    • Use: prostate CA
    • Continuous release
    • MOA: suppress HPG axis
  60. Cetrorelix
    • GnRH/analog
    • Use: precocious puberty (boys)/ endometriosis (female)
  61. Testosterone
    • Androgen
    • Use: hypogonadism/tx catabolic states (muscle wasting in AIDS)
  62. Testosterone Propionate
    • Androgen
    • Use: hypogonadism/tx catabolic states (muscle wasting in AIDS)
  63. Methyltestosterone
    • 17-alpha-alkylated androgen
    • Oral
    • SE: hepatotoxic/edema/jaundice
  64. Danazol
    • 17-alpha-alkylated androgen
    • Oral
    • SE: hepatotoxic/edema/jaundice
  65. Dutasteride
    • 5-alpha-reductase inhibitor
    • Use: tx BPH
    • SE: virilization in prepuberty/feminization in postpuberty/ suppress HPG axis/inc risk liver CA/anabolic
  66. Finasteride
    • 5-alpha-reductase inhibitor
    • Use: tx BPH
    • SE: virilization in prepuberty/feminization in postpuberty/ suppress HPG axis/inc risk liver CA/anabolic
  67. Bicalutamide
    Androgen Receptor antagonist
  68. Flutamide
    • Androgen Receptor antagonist
    • Use: prostate CA
  69. Nilutamide
    • Androgen Receptor antagonist
    • Use: prostate CA
  70. Growth Hormone
    • GH-related
    • SubQ/IM
    • SE: inject site rxn/HA
    • Adults: perif edema/carpal tunnel/dec glc tolerance/ hypothyroidism
    • Children: inc intracranial pressure
  71. Sermorelin acetate
    • GH-related/synthetic
    • SE: inject site rxn/HA
    • Adults: perif edema/carpal tunnel/dec glc tolerance/ hypothyroidism
    • Children: inc intracranial pressure
  72. IGF-1
    • GH-related/human recombinant
    • Use: only GH resistant cases
    • SE: inject site rxn/HA
    • Adults: perif edema/carpal tunnel/dec glc tolerance/ hypothyroidism
    • Children: inc intracranial pressure
  73. Pegvisomant
    • GH antagonist
    • binds better than wild-type
  74. Octreotide
    • Somatostatin agonist
    • MOA: bind 2 & 5 recept/avoid pancreas recept
    • SE: N/diarrhea/abdo pain/gallstones
  75. Lanreotide
    • Somatostatin agonist
    • MOA: bind 2 & 5 recept/avoid pancreas recept
    • SE: N/diarrhea/abdo pain/gallstones
  76. Bromocriptine
    • D2 agonist
    • MOA: inhib prolactin release
    • Use: tx hyperprolactinemia/amenorrhea/galactorrhea/ infertility/prevent lact post-abortion/miscarry
    • SE: N/HA/orthostatic hypo
  77. Cabergoline
    • D2 agonist
    • MOA: inhib prolactin release
    • Use: tx hyperprolactinemia/amenorrhea/galactorrhea/ infertility/prevent lact post-abortion/miscarry
    • SE: N/HA/orthostatic hypo
  78. Desmopressin
    • Posterior pituitary
    • MOA: V1=constrict/V2=resorb water
    • Use: replacement tx for DI
    • Not selective
  79. Oxytocin
    • Posterior pituitary
    • MOA: change ion current in SM of myometrium/ sustained contraction/induce labor
  80. Vasopressin
    • Posterior pituitary
    • MOA: V1=constrict/V2=resorb water
    • Use: replacement tx for DI
    • V2 selective
  81. Atosiban
    • Posterior pituitary antagonist
    • Use: tx premature labor
    • NOT USA
  82. Vitamin D
    • Vitamin D/analog
    • MOA: inc absorb of Ca/hypercalcemia
  83. Vitamin D2
    • Vitamin D/analog
    • MOA: inc absorb of Ca/hypercalcemia
    • Plant derivative
  84. Vitamin D3
    • Vitamin D/analog
    • MOA: inc absorb of Ca/hypercalcemia
    • Mammalian
  85. PTH
    MOA: dec Ca into urine/inc uptake from bone
  86. Calcitonin
    • MOA: inhib bone resorb/causes hypocalcemia
    • SubQ/nasal
  87. Alendronate
    • Bisphosphonate
    • MOA: Inhib enz in isoprenoid synth/inhib boen resorb/ hypocalcemia
    • Oral(poor absorb/esophagitis)/parentral
  88. Etidronate
    • Bisphosphonate
    • MOA: Inhib enz in isoprenoid synth/inhib boen resorb/ hypocalcemia
    • Parentral
  89. Pamidronate
    • Bisphosphonate
    • MOA: Inhib enz in isoprenoid synth/inhib boen resorb/ hypocalcemia
    • Parentral
  90. Risedronate
    • Bisphosphonate
    • MOA: Inhib enz in isoprenoid synth/inhib boen resorb/ hypocalcemia
    • Oral (poor absorb/esophagitis)/parentral
  91. Tiludronate
    • Bisphosphonate
    • MOA: Inhib enz in isoprenoid synth/inhib boen resorb/ hypocalcemia
    • Oral(poor absorb/esophagitis)/parentral
  92. Ferrous fumarate
    • Iron
    • Oral/not enteric coated
    • SE: cramps/N/constipation/diarrhea/black stool
    • Repletion 3-6 months
  93. Ferrous gluconate
    • Iron
    • Oral/not enteric coated
    • SE: cramps/N/constipation/diarrhea/black stool
    • Repletion 3-6 months
    • Less SE because less elemental Fe
  94. Ferrous sulfate
    • Iron
    • Oral/not enteric coated
    • SE: cramps/N/constipation/diarrhea/black stool
    • Repletion 3-6 months
  95. Deferasirox
    • Chelator
    • Use: Iron toxicity
    • Oral/fecal elim/
    • SE: HA/Renal tox
    • Repletion 2-3 weeks
  96. Deferoxamine
    • Chelator
    • Use: Iron toxicity
    • IV/Renal elim
    • SE: discolor at inject/HA/arthralgia/anaphylaxis (test dose)/OTO tox/OCULAR tox
    • Repletion 2-3 weeks
  97. Vitamin B12
    • Vitamin
    • Use: convert to succinyl-CoA/convert to methionine
    • Needs intrinsic factor to absorb in ilium
    • Use: suppliment deficient diet (vegetarian)
    • Oral/IV in pernicious anemia
  98. Erythropoietin
    • hematopoietic growth factor
    • Use: stim prolif/mature/hemoglobin form/stim early release of reticulocytes
    • SE: inc thrombosis/HTN/seizures/CA progression
  99. G-CSF
    • hematopoietic growth factor
    • MOA: stim granulocyte/neutrophil/release granulocytes from marrow
  100. GM-CSF
    • hematopoietic growth factor
    • MOA: stim granulocytes/monocytes/macrophages/ megakaryocytes
    • combo IL-3

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