Card Set Information
Mechanism of Action
Syntheic opioid agonist that acts on opioid receptors to produce analgesia, euphoria, respiratory and physical depression; a schedule II drug with potential for physical dependency and abuse.
Analgesia for moderate to severe pain.
Hypersensitivity to narcotic agents, diarrhea caused by poisoning, patients taking MAOI's, during labor or delivery of a premature infant, undiagnosed abdominal pain or head injury.
Respiratory depression, sedation, apnea, circulatory depression, arrhythmias, shock, euphoria, delirium, agitation, hallucinations, visual disturbances, coma, seizures, headache, facial flushing, increased ICP, nausea, vomiting.
Do not give concurrently with MAOI's (even with a dose in the last 14 days!). Exacerbates CNS depression when given with these medications.
50/mL in 1-mL prefilled syringes and Tubex.
Dosage and Administration
Adult: 50-100 mg IM, SC or 25-50 mg slowly IV.
Pediactric: 1-2 mg/kg/dose IV, IO, IM, SC.
Duration of Action
Onset: IM: 10-45 minutes; IV: immediate.
Peak Effect: 30-60 minutes.
Duration: 2-4 hours.
Pregnancy safety: Category C. Use with caution in patients with asthma and COPD. May aggravate seizures in patients with known convulsive disorders. Naloxone should be readily available as antagonist.