pharmacology final

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Author:
flucas
ID:
120764
Filename:
pharmacology final
Updated:
2011-12-05 16:54:27
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pharmacology
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pharmacology final
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  1. What are the ESKAPE organisms?
    • organisms that cause the most hospital infections annually
    • Enterococcus faecium
    • Staph. aureus
    • Klebsiella pneumoniae
    • Acinetobacter baumanii
    • Pseudomonas aeruginosa
    • Enterobacter specie
  2. How is chloramphenicol metabolized and excreted?
    chloramphenicol is first metabolized in the liver (glucoronidation) and then excreted by the kidneys
  3. Why are sulfamethoxazole and trimethoprim administered together (e.g. Bactrim)?
    • synergistic effect of sulfa/trim combo
    • work on different parts of folic acid pathway (sulfa: DHPS, tri: DHFR)
    • either in 5:1 or 20:1 ratios of sulfa:tri

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