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What are the ESKAPE organisms?
- organisms that cause the most hospital infections annually
- Enterococcus faecium
- Staph. aureus
- Klebsiella pneumoniae
- Acinetobacter baumanii
- Pseudomonas aeruginosa
- Enterobacter specie
How is chloramphenicol metabolized and excreted?
chloramphenicol is first metabolized in the liver (glucoronidation) and then excreted by the kidneys
Why are sulfamethoxazole and trimethoprim administered together (e.g. Bactrim)?
- synergistic effect of sulfa/trim combo
- work on different parts of folic acid pathway (sulfa: DHPS, tri: DHFR)
- either in 5:1 or 20:1 ratios of sulfa:tri
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