________ are generally well tolerated. Adverse reactions usually don’t require discontinuation of therapy.
Gastrointestinal effects (3-17%) – most common; n/v, abdominal pain but not diarrhea
*CNS agitation – Dizziness, headache, restlessness, depression, & insomnia in children (overall freq. = 1-10%); most occur more often in elderly patients. Seizures, delirium, and hallucinations rarely occur; such events occur primarily in patients also receiving theophylline or an NSAID (see below). The mechanism appears to involve blockade of GABA receptors in the CNS.
*Rashes, urticaria, pruritus, and photosensitivity reactions may occur. (Phototoxicity is most common with lomefloxacin; rashes are most common with gemifloxacin.)
*Prolongation of the QT interval has been observed with levofloxacin and moxifloxacin. ________ should be used with caution in patients receiving antiarrhythmics (amiodarone, quinidine, procainamide).
*________ are absolutely contraindicated in pregnancy, during nursing, and are not recommended in children (largely due to the possibility that it might damage cartilage). Recent studies suggest that the benefits might outweigh the risks in, for example, children with cystic fibrosis.