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2 Inhalational Anesthetics?
- Halothane-sevuflurane, Desflurane
What is MAC?
Minimal alveolar concentration that produces effects in 50 % of pts
What has a lower MAC, NO or Halothane?
What is the Blood/gas coefficeint?
proportion of the gas bound to albumin in blood compared to the free amount of it in the CNS
NO or halothane has a lower Blood/gas coefficeint?
A low Blood/gas coefficeint means what?
rapid induction and recovery from anesthesia
Where do anethetics redistribute and may cause side effects after the anesthetic wears of?
S/E of Halothane?
- malignant hypertension
- Cardiac arrythmias
What are the 5 IV anesthetics?
- Propofol--GABAa agonist
- Ketamine-NMDA antagonist
How is Propofol better than other IV anesthetics?
How is fentanyl better than other IV anethetics?
- it is an anesthetic
- it is an analgesic
2 families of Local anesthetics?
- esters--allergies bc they are PABA derivative
- Amide--depend on liver for metabolism
Which local anesthetic depends on liver metabolism?
- Amide with 2 I's
Local anesthetics preferentially attack which fibers?
small or large myelinated fiber? Myelinated or unmyelinated?
- small myelinated -pain is lost first
- Type B and C
Local anesthetics must be given with what to ensure its not absorbed systemically?
alpha 1 agonist such as epinephrine
Which local anesthetic causes CVS toxicity?
Which anethetic produces dissociative anesthesia?
WHich anesthetic increases cerebral blood flow?
decreases cerebral blood flow?
Anesthetic choice in kids?
Local anesthetics need what pH to be absorbed?
Local anesthetics work on what kind of sodium channels? activated or inactivated?
2 types of skeletal muscle relaxants?
Rx for overdose?
- depolarizing-non competitive-succinylcholine--i]
- nondepolarizing- competitive-curare
- cholinesterase inhibitors
To how many locations does ach bind to in Nicotinin muscarinic receptor?
How many molecules of curare are needed?
endings of non depolarizing skeletal muscle relaxants?
Depolarizing-competitive skeletal muscle relaxant?
what are the 2 phases?
- phase I--depolarizing
- phase II-desensitization
2 centrally acting skeletal muscle relaxants?
- benzodiazapine- GABAa receptors
- Baclofen-GABAb receptors