Anesthetics Pharm

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pszurnicki
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121027
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Anesthetics Pharm
Updated:
2011-12-05 18:52:31
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Anesthetics Pharm
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Anesthetics Pharm
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  1. 2 Inhalational Anesthetics?
    • NO
    • Halothane-sevuflurane, Desflurane
  2. What is MAC?
    Minimal alveolar concentration that produces effects in 50 % of pts
  3. What has a lower MAC, NO or Halothane?
    Halothane
  4. What is the Blood/gas coefficeint?
    proportion of the gas bound to albumin in blood compared to the free amount of it in the CNS
  5. NO or halothane has a lower Blood/gas coefficeint?
    NO
  6. A low Blood/gas coefficeint means what?
    rapid induction and recovery from anesthesia
  7. Where do anethetics redistribute and may cause side effects after the anesthetic wears of?
    FAT
  8. S/E of Halothane?
    • hepatitis
    • malignant hypertension
    • Cardiac arrythmias
  9. What are the 5 IV anesthetics?
    • Thiopental-barb
    • Midazolam-benzo
    • Propofol--GABAa agonist
    • Fentanyl/Morphine-opiod
    • Ketamine-NMDA antagonist
  10. How is Propofol better than other IV anesthetics?
    • less nausea
    • anti-emetic
  11. How is fentanyl better than other IV anethetics?
    • it is an anesthetic
    • it is an analgesic
  12. 2 families of Local anesthetics?
    • esters--allergies bc they are PABA derivative
    • Amide--depend on liver for metabolism
  13. Which local anesthetic depends on liver metabolism?
    • Amide with 2 I's
    • Lidocaine
    • Mepivacaine
    • Bupivacaine
  14. Local anesthetics preferentially attack which fibers?
    small or large myelinated fiber? Myelinated or unmyelinated?
    • small myelinated -pain is lost first
    • Type B and C
  15. Local anesthetics must be given with what to ensure its not absorbed systemically?
    alpha 1 agonist such as epinephrine
  16. Which local anesthetic causes CVS toxicity?
    Arrhytmias?
    • bupivacaine
    • cocaine
  17. Which anethetic produces dissociative anesthesia?
    Ketamine
  18. WHich anesthetic increases cerebral blood flow?
    decreases cerebral blood flow?
    • Ketamine
    • Thiopental
  19. Anesthetic choice in kids?
    Ketamine
  20. Local anesthetics need what pH to be absorbed?
    alkaline
  21. Local anesthetics work on what kind of sodium channels? activated or inactivated?
    inactivated
  22. 2 types of skeletal muscle relaxants?
    Rx for overdose?
    • depolarizing-non competitive-succinylcholine--i]
    • nondepolarizing- competitive-curare
    • cholinesterase inhibitors
  23. To how many locations does ach bind to in Nicotinin muscarinic receptor?
    How many molecules of curare are needed?
    • 2
    • 1
  24. endings of non depolarizing skeletal muscle relaxants?
    -curium
  25. Depolarizing-competitive skeletal muscle relaxant?
    what are the 2 phases?
    • succinylcholine
    • phase I--depolarizing
    • phase II-desensitization
  26. 2 centrally acting skeletal muscle relaxants?
    • benzodiazapine- GABAa receptors
    • Baclofen-GABAb receptors

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