Vasculitides

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Author:
blakegoodman08
ID:
121114
Filename:
Vasculitides
Updated:
2011-12-05 22:29:04
Tags:
S3M3 S3 Ross University Medical Med School pathology cardiovascular
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Description:
Quick rundown of the major vasculitides
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  1. 5 classifications of vasculitides
    • Large vessel: granulomatous
    • Medium vessel: anti-endothelial or immune complex
    • Small vessel: ANCA or immune complex
    • Infectious
    • Other
  2. 2 large vessel vasculitides
    • Giant cell (temporal) vasculitis: most common adult vasculitis, F>M; cell-mediated immune rxn; granulomas
    • Takayasu arteritis: <40yoa, F>M; narrowing of carotid, subclavian (pulseless); granulomatous, intimal fibrosis
  3. 2 medium vessel vasculitides
    • Polyarteritis nodosa: segmental transmural necrotizing; 30% with HepB antibodies; young adults; renal failure, 2* hypertension
    • Kawasaki disease: transmural necrotizing; coronary artery involvement; 2* to viral/bacterial infection; <5yoa; rash and strawberry tongue
  4. 3 small vessel vasculitides
    • Microscopic polyangiitis: p-ANCA (MPO); 50yoa; no granulomas, asthma; segmental necrotizing; hypersensitivity (rash)
    • Churg-Strauss syndrome: p-ANCA (MPO); 50yoa; bronchial asthma; necrotizing granulomas with eosinophils
    • Wegener granulomatosis: c-ANCA (PR3); adult; necrotizing granulomas in upper airway/lungs, kidneys
  5. 3 "other" vasculitides
    • Thromboangiitis obliterans: aka Buerger; smokers; gangrene extremeties; stop smoking
    • Henoch-Schonlein purpura: most common child vasculitis; IgA and complement immune deposits; follows infection (viral, strepA); self-limited
    • Raynaud disease: cold-induced vasospasm, part of CREST

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