Ocular Drugs

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Author:
mpgcuenca
ID:
121489
Filename:
Ocular Drugs
Updated:
2011-12-07 03:27:59
Tags:
Ocular Pharmacology
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Description:
Ocular Drugs
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  1. PROSTAGLANDIN ANALOGUES (PGA)
    • Latanoprost (XALATAN)
    • Travoprost (TRAVATAN)
    • Bimatoprost (LUMIGAN)
  2. MoA
    • Lowers intraocular pressure by facilitating aqueous outflow through
    • the accessory uveoscleral outflow pathway by a pathway involving
    • the prostanoid FP receptor. The IOP-lowering effects of PG
    • analogues including latanoprost, travoprost, bimatoprost, and
    • unoprostone were completely eliminated in FP receptor knockout
    • mice
  3. SEs
    • Few safety concerns, mainly cosmetics such as conjunctival
    • hyperemia, darkening of the iris by increasing the number of
    • melanosomes in melanocytes (7% of patients). Lengthening and
    • darkening of eyelashes,reactivation of herpetic keratitis and
    • anterior uveitis, and cystoid macular edema following cataract
    • surgery have been reported with their use.
    • Mechanism of action of mitotic agents and prostaglandin analogues
    • are antagonistic

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