Card Set Information
Systemic Carbonic anhydrase inhibitors (CAIs)
Sulfonamide derivative used systemically to treat open angle glaucoma.
Can treat macular edema and other macular degeneration diseases
Inhibition of carbonic anhydrase (CA) isozymes present in ciliary
processes of the eye (such as CA II, IV and XII), with the consequent
reduction of bicarbonate and aqueous humour secretion, and of elevated
intraocular pressure (IOP).
Since CA II/IV/XII are present in many other tissues/organs, (CNS,
erythrocytes, pancreas, gastric mucosa, kidney), systemic CAIs possess
undesired side effects such as numbness and tingling of extremities,
somnolence (CNS); metallic taste; depression; fatigue; malaise; weight
loss; decreased libido; gastrointestinal irritation; metabolic acidosis; renal
calculi (precipitation of calcium phosphate salts in an alkaline urine) and
transient myopia. Contraindicated in patients with sulfa allergy.