Ocular Drugs

Card Set Information

Author:
mpgcuenca
ID:
121492
Filename:
Ocular Drugs
Updated:
2011-12-07 03:53:55
Tags:
Ocular Pharmacology
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Description:
Ocular Drugs
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  1. Systemic Carbonic anhydrase inhibitors (CAIs)
    Acetazolamide (DIAMOX)
  2. Indication
    • Sulfonamide derivative used systemically to treat open angle glaucoma.
    • Can treat macular edema and other macular degeneration diseases
  3. MoA
    • Inhibition of carbonic anhydrase (CA) isozymes present in ciliary
    • processes of the eye (such as CA II, IV and XII), with the consequent
    • reduction of bicarbonate and aqueous humour secretion, and of elevated
    • intraocular pressure (IOP).
  4. SEs
    • Since CA II/IV/XII are present in many other tissues/organs, (CNS,
    • erythrocytes, pancreas, gastric mucosa, kidney), systemic CAIs possess
    • undesired side effects such as numbness and tingling of extremities,
    • somnolence (CNS); metallic taste; depression; fatigue; malaise; weight
    • loss; decreased libido; gastrointestinal irritation; metabolic acidosis; renal
    • calculi (precipitation of calcium phosphate salts in an alkaline urine) and
    • transient myopia. Contraindicated in patients with sulfa allergy.

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