Ocular Drugs

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  1. Anticholinesterase agents
    Physostigmine (ERERINE)
  2. Indication
    • Glaucoma, accommodative esotropia. Physostigmine is also used for
    • louse and mite infestation of lashes.
  3. MoA
    • Increase parasympathetic activity by inhibiting cholinesterase, thereby
    • permitting the accumulation of acetylcholine and prolonging the activity on
    • the effector end organs of the eye.
  4. SEs
    • Vitreous hemorrhaging, contact dermatitis, allergic conjunctivitis.
    • Echothiophate produces the most severe symptoms including discomfort
    • associated with bright lights and close-up work, affected eye is extremely
    • myopic. Systemic absorption of the long acting agents may produce GI
    • disturbances (nausea, diarrhea, and abdominal pain), muscle spasm,
    • weakness, sweating, lacrimation, salivation, hypotension, bradycardia,
    • bronchial constriction, respiratory failure. Most systemic effects reverse
    • rapidly after drug has been discontinued. In severe toxicity give atropine
    • sulfate (2mg) or pralidoxime chloride 25mg/kg iv or sc with no effect on
    • glaucoma.
    • These agents are no longer commonly used in clinical practice, but may
    • play a role in the management of selected patients.
Card Set
Ocular Drugs
Ocular Drugs
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