Card Set Information
Glaucoma, accommodative esotropia. Physostigmine is also used for
louse and mite infestation of lashes.
Increase parasympathetic activity by inhibiting cholinesterase, thereby
permitting the accumulation of acetylcholine and prolonging the activity on
the effector end organs of the eye.
Vitreous hemorrhaging, contact dermatitis, allergic conjunctivitis.
Echothiophate produces the most severe symptoms including discomfort
associated with bright lights and close-up work, affected eye is extremely
myopic. Systemic absorption of the long acting agents may produce GI
disturbances (nausea, diarrhea, and abdominal pain), muscle spasm,
weakness, sweating, lacrimation, salivation, hypotension, bradycardia,
bronchial constriction, respiratory failure. Most systemic effects reverse
rapidly after drug has been discontinued. In severe toxicity give atropine
sulfate (2mg) or pralidoxime chloride 25mg/kg iv or sc with no effect on
These agents are no longer commonly used in clinical practice, but may
play a role in the management of selected patients.