BMS1-Immuno1

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fallcloud13
ID:
121578
Filename:
BMS1-Immuno1
Updated:
2011-12-08 12:27:37
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BMS
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Description:
BMS1-Dr.Milks' -(1)
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  1. aldesleukin
    • Proleukin
    • IL-2
    • Immunomodulator: lymphocyte mitogenesis, cytotoxicity, LAK, NK cells, IFN-gamma
    • Indications: metastatic renal cell carcinoma, metastatic melanoma
    • E-coli, 15,300
  2. oprelvekin
    • Neumega
    • IL-11
    • Stimulates megakaryocytes and platelet formation
    • Indications: prevention of severe thrombocytopenia, myelosuppressive chemotherapy
    • Adverse effects: fluid retention, edema, cardiovascular
    • E.Coli, 19,000
  3. ancestim
    • Stemgen
    • recombinant methionyl human stem cell factor (r-metHuSCF)
    • soluble human stem cell factor (c-kit ligand)
    • E. coli, Sub-Q, 18,500
  4. interferon alfa-2a, recombinant (rIFN-a2a)
    • Withdrawn
    • Indications: chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi sarcoma, chronic myelogenous leukemia (CML)
    • Adverse effects: autoimmune diseases, flu-like symptoms, neuropsychiatric, ischemic, infections
    • E. coli
  5. peginterferon alfa-2a
    • Pegasys
    • Indications: chronic hepatitis B, C
    • Longer half-life
  6. interferon a2b recombinant (IFN-a2b)
    • Intron A
    • Indications: hairy cell leukemia, malignant melanoma, follicular lymphoma, condylomata acuminata, AIDS-related Kaposi's sarcoma, chronic hepatitis C, B
    • E. coli
  7. peginterferon alfa-2b
    • PegIntron
    • Indications: chronic hepatitis C
    • Redipen, vials
    • Sylatron
    • Indications: melanoma
  8. interferon alfa-n3
    • Alferon N
    • human leukocyte derived
    • Indications: condylomata acuminata
  9. interferon alfacon-1
    • Infergen
    • recombinant interferon alfa, consensus interferon (CIFN)
    • Indications: chronic hepatitis C
    • E. coli, 5X activity
  10. interferon-b1a (IFN-b1a)
    • Rebif, Avonex
    • Identical to human IFN-b
    • Indications:relapsing forms of multiple sclerosis (MS)
    • CHO
  11. interferon-b1b (IFN-b1b)
    • Betaseron, Extavia
    • slight variant to human IFN b
    • Indications:relapsing forms of multiple sclerosis (MS)
    • E. coli
  12. interferon-y1b (IFN-y1b)
    • Actimmune
    • Indications: chronic granulomatous disease, malignant osteopetrosis
  13. T-cell Antigens
    • CD2
    • CD3
    • CD4
    • CD8
    • TCR
    • CD28
  14. B-cell Antigens
    • CD19 - Signal transducing
    • CD20
    • CD21 - CR-2
    • CD32 - Fc receptors
    • CD81 - co-receptor
    • sIgM
  15. NK-cell Antigens
    • CD16 - Fc receptor causing ADCC
    • CD56
  16. Treg cell Antigens
    • CD25
    • FoxP3
    • CTLA-4 (CD152)
  17. Cytokines that mediate Natural Immunity
    • IL-1: Macrophage secreted
    • TNF-a: Macrophage secreted
    • Type 1 INFs: INF-a, b
    • IL-6: Monokine + TH2
  18. Cytokines that regulate Lymphocyte growth, activation, and differentiation
    • IL-2: * T-cell, B-cell proliferation
    • IL-4: TH2
  19. Cytokines that activate Inflammatory Cells
    • IFN-y: TH1
    • TNF-a
    • IL-5
  20. Cytokins that affects Leukocyte movement
    • IL-8: macrophage, epithelia cells, synthesized by endothelial cells
    • Other chemokines
  21. Cytokins that stimulate Hemotopoiesis
    • G-CSF
    • GM-CSF
    • c-kit ligand
  22. Hypersensitivity Type I (Anaphylactic Type)
    • Vasodilation: Histamine, hypotension
    • Vascular permeability: edema
    • Smooth muscle spasn: bronchoconstriction, GI hyper motility
    • Cellular infiltration: chemotaxins
    • IgE synthesis: IL-4*, IL-5, IL-6
  23. Hypersensitivity Type II (Cytotoxic Type)
    • Autoimmune hemolytic anemia
    • Autoimmune thrombocytopenic pupura
    • Goodpasture syndrome: Nephritis, Lung hemorrhage
    • Myasthenia gravis
    • Graves disease
    • Erythroblastosis
  24. Hypersensitivity Type III (Immune complex-mediated)
    • Systemic lupus erythematosus
    • Poststreptococcal glomerulonephritis
    • Acute glomerulonephritis
    • Arthus reaction
    • Serum sickness
  25. Hypersensitivity Type IV (Cell-mediated)
    • Delayed-type (TH1), T-cell-mediated (Tc)
    • Type 1 diabetes mellitus
    • Multiple sclerosis
    • Rheumatoid arthritis
    • Peripheral neuropathy; Guillain-barre syndrome
    • TB test, Poison Ivy
  26. Hyperacute Rejection
    Immune complexes: Type III hypersensitivity
  27. Acute Rejection
    • Humoral: Type III and Type II hypersensitivity
    • complement-dependent cytotoxicity
  28. Subacute cellular rejection
    • Type IV hypersensitivity
    • In couple of months
    • mononuclear cell infiltration: Tc, NK, TH, macrophage
  29. Chronic Rejection
    • Type IV hypersensitivity: accumulating fibrosis
    • interstitial mononuclear cell infiltration: activated macrophage
    • delayed-type: TH1: IL-2, IFN-y
  30. Severe Combined ImmunoDeficiency (SCID)
    • adenosine deaminase deficiency: both T, B-cell
    • Tx: pegademase bovine, bon marrow transplant, gene therapy
  31. DiGeorge Syndrome (thymic hypoplasia)
    • Failure of development of the Thymus
    • Tx: bone marrow transplantation, fetal thymus transplantation
  32. Bruton's Congenital Agammaglobulinemia
    • X-linked: absence of mature B-cell
    • Tx: frequent immuno globulin injection
  33. Common Variable Immunodeficiency
    Decreased plasma cell number
  34. Isolated IgA Deficiency
    • Most common: increase pulmonary and GI infection
    • Can develope anti-IgA antibodies

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