Used to be considered a parasite, but no recognized as a fungus,
Life cycle: troph, precyst, cyst
Cell wall different than other fungi (no glucan or N-acetulclucosamine)
Most common opportunistic infection associated w/ HIV
progressive diffuse pneumonia, tachyapnea, dyspnea w/ cyanosis and hypoxia; slow onset w/ low grade fever; diffuse infiltrate on CXR; disseminates to lymph nodes, bone marrow, spleen, liver, thyroid, GI tract, kidneys
by induced sputum or bronchoscopy; look for organism: methamine silver, DFA, other stains.