Chapter 7 Patho

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Author:
adnap28
ID:
121719
Filename:
Chapter 7 Patho
Updated:
2011-12-07 22:01:30
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Immune Deficiency
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Immune Deficiency
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  1. Immunologic responses recognized as diseases are:
    immediate and delayed hypersensitivity
  2. Which is not a characteristic of hypersensitivity?
    prior contact unnecessary to elicit response
  3. When the body produces antibodies against its own tissue, it is :
    an autoimmune disease
  4. Which hypersensitivity is caused by poison ivy?
    Type 3
  5. The mechanism of hypersensitivity for drugs is ?
    Type 1
  6. Whichis not an autoimmune disease?
    transfusion reaction
  7. Damage in systemic lupus erythematosus results from teh formation of antigen/antibody complexes mediated by:
    the humoral immune system and complement
  8. The classical complement cascade begins with:
    antigen/antibody complexes binding to a component of the complement system
  9. An alloimmune disorder is:
    erythroblastois fetalis
  10. Immunodeficiencies occur because of impaired function of :
    • B and T cells
    • phagocytic cells
    • complement
  11. An X-linked recessive disorder of immune deficiency involves a deficit of :
    IgM
  12. Deficiencies in B cell immune responses are suspected when unusual or recurrent severe infections are caused by:
    encapsulated bacteria
  13. DiGeorge syndrome is a primary immune deficiency caused by
    congential lack of thymic tissue
  14. Secondary or aquired immondeficiencies:
    • develop after birth
    • may be caused by viral infections
    • may develop following immunosuppressive therapy
  15. Rejection of a kidney transplant ocurred after 2 weeks. The reaction was because of:
    • immune response against donor HLA antigens
    • a type 4 hypersensitivity
  16. SCID exhibits:(severe combined immune deficiences)
    B cell deficiencies
  17. A positve HIV antibody test signifies that the:
    individual is infected with HIV and likely so for life
  18. Which is incorrect regarding AIDS?
    The patient will have increased numbers of CD 4 or helper T cells
  19. What is Hypersensitivity?
    it is an inappropriate immune response misdirected against the host's own tissures (autoimmunity) or directed against beneficial foreign tissues, such as transfusions or transplants (alloimmunity) or it can be exaggerated responses against enviromental antigens (allergy)
  20. How Hypersensitivity is classified:
    • Type 1: IgE mediated (allergies)
    • Type 2: Tissue Specific (drug reactions, autoimmunity or blood transfusions)
    • Type 3: Immune Complex (systemic lupus)
    • Type 4: Cell Mediated (RA, contact dermititis)
  21. Exotoxins versus Endotoxins:
    • Bacteria injure cells by producing exotoxins or endotoxins.
    • Exotoxins are enzymes that can damage the plasma membranes of host cells or can inactivate exzymes critical for protien synthesis
    • Endotoxins activate the inflammatory response and produce a fever
  22. What is Septicemia?
    is the proliferation of bacteria in blood. Endotoxins released by blood borne bacteria cause the release of vasoactive enzymes that increase the permeability of blood vessels. Leakage from vessels causes hypotension that can result n septic shock.
  23. What do viruses do?
    • may decrease protein synthesis
    • disrupt lysosomal membraes and form inclusion bodies where synthesis of viral nucleic acids is occuring
    • fuse with host cells to produce giant cells
    • alter antigenic properties of the host cell
    • transform host cells into cancerous cells
  24. Immunodeficiency is:
    the failure of teh mechanisms of self defense to function in their normal capacity
  25. Congenital or Aquired Immunodeficiency:
    • Congenital (primary) are caused by genetic defects that disrupt lymphocyte development
    • Aquired (secondary) are secondary to diseases or other physiologic alterations

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