Solid Oral and Non-oral Modified-Release

Card Set Information

Author:
ANVigil
ID:
121904
Filename:
Solid Oral and Non-oral Modified-Release
Updated:
2011-12-08 14:40:12
Tags:
Dose Form Final
Folders:

Description:
Dose Form Final
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The flashcards below were created by user ANVigil on FreezingBlue Flashcards. What would you like to do?


  1. One dose for immediate release and another dose for delayed release (or 2nd dose)
    Multiple layered or tablet within a tablet
    Repeat action
  2. Release is direct toward a specific body region, tissue, or site
    enteric coating
    Target release
  3. Rate controlled delivery systems
    • applicable to numerous dosage forms
    • rate of drug delivery is controlled by feature of the device
  4. MTC
    Minimum Toxic Concentration
  5. MEC
    Minimum effective concentration
  6. Advantages of Solid Oral Modified-Release
    • Reduction in drug blood level fluctuations
    • Frequency reduction in dosing
    • Enhanced convenience and compliance
    • Reduction in side effects
    • Reduction in overall helath care costs
  7. Disadvantages of Solid Oral Modified-Release
    • No flexibility in adjusting drug dose and or dosage regiment
    • Dose dumping
  8. What are the attributes of drugs that are good candidates for extended-release products
    • Neither very slow nor very fast rates of absorption and excretion (inherently long-acting drugs and short life)
    • Uniformly absorbed from GI tract
    • Administered in relatively small doses
    • Good margin of safety, wide therapeutic index
  9. Therapeutic index
    median toxic dose/median effective dose
  10. Oral extended-release products
    • Provide immediate release of one dose of drug for prompt therapeutic effect followed by gradual and continual release of additional doses to maintain effect over an extended period of time
    • Additional "maintenance" doses are released at a rate correspondent to the amount being metabolized and excreted
    • Dissolve in GI fluids
    • Maintain sufficient GI residence time
  11. Extended-release technolgoy
    • Coated beads, granules or microspheres
    • Multitablet system
    • Microencapsulated drug
    • Drug embedded in slwly eroding or hydrophilic matrix
    • Drug embedded in inert plastic matrix
    • Complex formation
    • Ion-exchange resins
    • Osmotic pump
  12. Doryx
    Coated doxycycline hyclate pellets
  13. Eric
    erythromycin delayed-release capsules with enteric coated pellets of erythromycin base

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