Baker's Exam 3: Diabetes Medications
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What mechanism category are: Glimepride, Glipizide, and Glyburide?
2nd Generation Sulfonylureas ("g" drugs)
What mechanism category are: Acarbose and Miglitol?
What mechanism category are: Pioglitazone and Rosiglitazone?
What mechanism category is metformin?
What mechanism category are: Nateglinide and Repaglinide?
What are the common dentally significant adverse effects of Sulfonylureas?
Can cause hypoglycemia and GI disturbances
What are the common dentally significant adverse effects of Alpha-glucosidase Inhibitors?
- GI disturbances
What are the common dentally significant adverse effects of Meglitinides?
Can cause hypoglycemia
What does the addition of a second oral drug or insulin indicate?
More severe diabetes
What is the major tx impact of each diabetes drug category?
- Sulfonylureas and insulin are the most significant as they can cause the most significant hypoglycemia during dental treatment
- Sulfonylureas: Hypoglycemia, watch for oral ulcers
- Alpha-Glucosidase Inhibitors: NO hypoglycemia
- Glitazones: no hypoglycemia
- Metglitinides & Biguanides: possible hypoglycemia
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