BIOL380 Cyclin Dependent Kinases
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What determines how cells move from stages G1, S, and G2?
What are the three Cyclin types?
- G1 Cyclin
- S Cyclin
- M Cyclin
What does CAK stand for?
Cyclin Dependent Kinase Activating Kinase
What does CAK do?
CAK adds a Phosphate to the Activation Site of a CDK
What needs to be in the CDK before CAK can phosphorylize the CDK Activation Site?
What adds a Phosphate to the CDK Inhibitory Site?
What removes Phosphates from the CDK Inhibitory Site?
CDC 25 Phosphitase
What does CDC stand for?
Cell Division Cycle Protein
What are the two functions of G1 CDK?
- Inactivate cdh-1
- Activate S CDK
When do G1 Cyclins concentrations increase?
At the end of Mitosis and continue to increase to the end of G1.
When do S Cyclin concentrations increase?
At the end of G1
What is the first step to activate the S CDK?
Degradation of the Inhibitory Protein
What phosphorylates the Inhibitory Protein on the Inactive S CDK?
Active G1 CDK
After the S CDK Inhibitory Protein is phosphorylated, what is the next step to Degradation of that Inhibitory Protein?
SCF to add a string of Ubiquitin
What does Ubiquitin do?
Triggers degradation of the Inhibitory Protein by attracting Proteosone
What does ORC stand for?
Origin of Replication Complex
What does CDC6 do?
It sits on the Origin of Replication Complex so that there's NO REPLICATION during G1
What does S CDK do to CDC 6?
S CDK adds a phosphate to CDC 6 destabilizing the CDC 6 and CDC 6 pops off ORC.
What does S CDK do to the ORC?
Adds a Phosphate
Once ORC is phosphorylated, what occurs?
What are 3 the function of M CDK?
- Triggers condensation of chromosomes.
- Phosphorylates Intermediate Filaments to break down nuclear membrane.
- Activates APC.
What indirectly causes the condensation of DNA?
How does M CDK activate APC?
Helps APC bind to CDC 20
What does APC do?
Adds a Ubiquitin chain to Securin
What does Securin do?
What does Separase do?
Breaks down Cohesin
What does Cohesin do?
Holds the Sister Chromatids together
What does M-CDK do during Mitosis?
- Formation of the Spindle Apparatus.
- Lining up of Chromosomes at Metaphase Plate.
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