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What are the two types of cell death?
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What triggers Cell Death?
Caspases
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What are the 3 Caspases that are Initiator Caspases?
2, 8, 9
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What are the 3 Caspases that are Executioner Caspases?
3, 6, 7
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What is the Main Function of Iniator Caspaces?
To activate other caspases.
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What keeps a Caspase inactive?
the Domain
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What are the two Pathways of Activation for Iniator Caspace?
- Extrinsic Pathway
- Intrinsic Pathway
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The T-Lymphocyte is related to which of the 2 pathways for Activation of Iniator Caspase?
Extrinsinc
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What does the T-Lymphocyte have so that it can bind to Infected Cells?
Fas Ligands
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What does the Infected Cell have so that T-Lymphocytes can bind to the Infected Cell?
Fas Receptors
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What does the binding of Fas Ligands and Fas Receptors result in?
The binding of Adapters inside the Infected Cell to the Fas Receptors
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What happens once the Adapters bind to the Fas Receptors inside the Infected Cell?
Procaspases will bind to the adapters
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What are Procaspases?
Inactive Caspases
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Once the Procaspaces bind to the Adapters, what happens next?
The Procaspases line up and activate each other.
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Where does Cytochrome C need to be in order for the Cell to tell something's wrong?
In the Cytoplasm
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What is the major component of the Intrinsic Pathway of Activation of Caspases ?
Cytochrome C
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What are the Receptors (located in the Cytoplasm) for Cytochrome C?
APAF-1
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What do the APAF-1 do once they're bound to Cytochrome C?
APAF-1 begin to bind to each other.
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After APAF-1 receptors start lining up with each other while they're bound to Cytochrome C, what happens next?
Procaspaces bind to APAF-1, lineup and initiate each other.
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What are the two Inhibitors of Apoptosis?
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Where is Bcl-2 usually located?
Mitochondrial Membrane
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What is the function of Bcl-2?
Inhibits release of Cytochrome C
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Where are IAP Proteins usually located?
In the Cytoplasm, but can also be in the MItochondria
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What does IAP stand for?
Inhibitors of Apoptosis Proteins
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What are the 3 Pro-Apoptotic Proteins?
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What is the function of the Pro-Apoptotic Protein Bad?
Inhibts Bcl-2
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What is the function of Bak and Bax?
To trigger the mitochondria to release Cytochrome C into the cytoplasm.
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What advantage does Apoptosis have over Necrosis?
Apoptosis doesn't make a mess and is more controlled.
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