BIOL380 - Cell Death

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BIOL380 - Cell Death
2011-12-11 18:22:18
BIOL380 Cell Death

BIOL380 - Cell Death
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  1. What are the two types of cell death?
    • Necrosis
    • Apoptosis
  2. What triggers Cell Death?
  3. What are the 3 Caspases that are Initiator Caspases?
    2, 8, 9
  4. What are the 3 Caspases that are Executioner Caspases?
    3, 6, 7
  5. What is the Main Function of Iniator Caspaces?
    To activate other caspases.
  6. What keeps a Caspase inactive?
    the Domain
  7. What are the two Pathways of Activation for Iniator Caspace?
    • Extrinsic Pathway
    • Intrinsic Pathway
  8. The T-Lymphocyte is related to which of the 2 pathways for Activation of Iniator Caspase?
  9. What does the T-Lymphocyte have so that it can bind to Infected Cells?
    Fas Ligands
  10. What does the Infected Cell have so that T-Lymphocytes can bind to the Infected Cell?
    Fas Receptors
  11. What does the binding of Fas Ligands and Fas Receptors result in?
    The binding of Adapters inside the Infected Cell to the Fas Receptors
  12. What happens once the Adapters bind to the Fas Receptors inside the Infected Cell?
    Procaspases will bind to the adapters
  13. What are Procaspases?
    Inactive Caspases
  14. Once the Procaspaces bind to the Adapters, what happens next?
    The Procaspases line up and activate each other.
  15. Where does Cytochrome C need to be in order for the Cell to tell something's wrong?
    In the Cytoplasm
  16. What is the major component of the Intrinsic Pathway of Activation of Caspases ?
    Cytochrome C
  17. What are the Receptors (located in the Cytoplasm) for Cytochrome C?
  18. What do the APAF-1 do once they're bound to Cytochrome C?
    APAF-1 begin to bind to each other.
  19. After APAF-1 receptors start lining up with each other while they're bound to Cytochrome C, what happens next?
    Procaspaces bind to APAF-1, lineup and initiate each other.
  20. What are the two Inhibitors of Apoptosis?
    • Bcl-2
    • IAP Proteins
  21. Where is Bcl-2 usually located?
    Mitochondrial Membrane
  22. What is the function of Bcl-2?
    Inhibits release of Cytochrome C
  23. Where are IAP Proteins usually located?
    In the Cytoplasm, but can also be in the MItochondria
  24. What does IAP stand for?
    Inhibitors of Apoptosis Proteins
  25. What are the 3 Pro-Apoptotic Proteins?
    • Bad
    • Bak
    • Bax
  26. What is the function of the Pro-Apoptotic Protein Bad?
    Inhibts Bcl-2
  27. What is the function of Bak and Bax?
    To trigger the mitochondria to release Cytochrome C into the cytoplasm.
  28. What advantage does Apoptosis have over Necrosis?
    Apoptosis doesn't make a mess and is more controlled.