Leptin, Adiponectin, TNFa & IL6 (Sands)

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Author:
catitasilva
ID:
122857
Filename:
Leptin, Adiponectin, TNFa & IL6 (Sands)
Updated:
2011-12-11 20:32:25
Tags:
Leptin Adiponectin TNFa IL6 Sands
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Leptin, Adiponectin, TNFa & IL6 (Sands)
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  1. Adiponectin
    • adipose derived cytokine
    • down regulated in obese
    • decreases inflammation
    • inc. FA oxidation, dec. FA synthesis
  2. Leptin
    • associated w/fat (higher in women)
    • dec. food intake, inc. energy expenditure
    • hypertension
    • increases inflammation
    • inhibits bone formation
    • Affects reproduction, puberty, pregnancy
  3. TNF-alpha
    • cytokine
    • inc. serum FA
    • inc. insulin resistance - impairs signaling
    • dec. adiponectin
    • inc. IL1 & IL6
  4. IL-6
    • inc. FFA & fatty oxidation
    • inc. serum glucose
    • down regulates IRS-1, GLUT4, adiponectin

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