Diabetes Pharm

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Author:
catitasilva
ID:
122884
Filename:
Diabetes Pharm
Updated:
2011-12-11 21:16:05
Tags:
diabetes pharm
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Description:
diabetes pharm
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  1. Problem in Type 2 diabetes?
    • insulin resistance (muscle, adipose & liver)
    • insulin secretion deficiency
    • increased hepatic glucose production
  2. Pharmacotherapy for the following problems:
    insulin resistance (muscle, adipose & liver)
    insulin secretion deficiency
    increased hepatic glucose production
    • insulin resistance (muscle, adipose & liver) - insulin sensitizers (TZD, glitazones, biguanides)
    • insulin secretion deficiency - secretagogues (sulfonylureas & incretine mimetric)
    • increased hepatic glucose production - slow carb absorption (a-glucosidase inhibitors)
  3. Rosiglitazone
    • TZD
    • selective agonist PPARg-R
    • activates insulin response genes in fat, muscle & liver
  4. Metformin
    • biguanide
    • activates AMPK
    • reduces hepatic gluconeogenesis & glycolysis
  5. Glyburide
    • sulfonylurea
    • inactivates SUR1
  6. Exenatide
    • incretine mimic
    • GLP1-R agonist
    • inc. insulin secretion & suppress glucagon secretion
    • induces satiety
  7. Acarbose
    • Alpha glucosidase inhibitor
    • inhibits polysaccharide breakdown by inhibiting E
    • slows down intestinal carb absorption
    • blunts post prandial rise in plasma glucose

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