Self Care- Acne Treatment (keratolytics)

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Author:
mwill222
ID:
122886
Filename:
Self Care- Acne Treatment (keratolytics)
Updated:
2011-12-11 21:17:37
Tags:
pharmacy acne
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Description:
Fall 2011 PT Module III: Acne
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  1. What are (7) non-pharmacological treatments of acne?
    • wash face twice daily (mild soap/cleanser)
    • avoid oily skin products
    • avoid squeezing/manipulating lesions
    • stay well hydrated
    • pore strips
    • oil absorbing strips
  2. What's the mechanism of action of Soap?
    removal of excess sebum & oil---lipohilic center & hydrophilic heads
  3. What are the side effects of soap?
    excessive drying/peeling
  4. What are the (5) Keratolytics?
    • Benzoyl peroxide
    • Salicylic acid
    • Sulur compounds
    • Resorcinol
    • Azelaic acid
  5. What is the MOA of benzoyl peroxide?
    • Keratolytic- breaks up keratin
    • Exfoliative- Desquamation
    • Comedolytic- solubilizes proteins
    • Bactericidal- oxygen radicals (dibenzoic acid)
  6. What are the side effects of benzoyl peroxide?
    • irritation, drying, peeling, erythema
    • bleaching
    • contact dermatitis- with 1st application
    • photosensitivity
  7. When to use benzoyl peroxide in therapy?
    • mild acne- monotherapy
    • moderate to severe- in combination
  8. What are the benzoyl peroxides directions?
    • Apply once to twice daily to clean, dry skin
    • 30 min after washing face
    • Titrate- test patch 15 min, then double time for each application until reach 4 hrs. Then try overnight then more than once a day.
  9. What is the Preg Category for BPO?
    C
  10. What is the age for BPO?
    greater than 12yrs
  11. What is the MOA for salicylic acid?
    • Kearatolytic
    • Solubilizes intracellular cement
    • decreases corneocyte adhesion
    • Desquamation
    • Comedolytic
  12. What are the side effects of salicylic acid?
    • irritation
    • inflammation
    • erythema
    • salicylism---N/V/D, tinnitis, dizzieness (rare w/ topical)
  13. When to use salicylic acid?
    mild acne- less efficacious, fewer side effects, easier to use
  14. What are the directions for salicylic acid?
    Apply 1-3 times daily to clean dry skin (do not need to titrate but can for dryness)
  15. What is the Preg Category for salicylic acid?
    C
  16. What age can salicylic acid be used?
    greater than 12yrs
  17. What is the MOA for sulfur compounds?
    • Keratolytic
    • Desquamation
    • Unproven Antibacterial effects
  18. What are the side effects of sulfur compounds?
    • stain
    • odor
    • comedogenic- triggers comedone formation
  19. Where are sulfur compunds most commonly found?
    with sulfonamides
  20. When are sulfur compunds used?
    • 2nd line in mild acne
    • use limited to side effects
  21. What are the directions of sulfur compounds?
    Apply 1-3 times daily
  22. What is the Preg Category of sulfur compounds?
    C
  23. What age can sulfur compounds be used?
    greater than 12ys
  24. When is Resorcinol used?
    • in combo with sulfur
    • enhances the keratolytic effects of sulfur
  25. What are the side effects of Resorcinol?
    reversible brown scaling of skin
  26. What is the MOA of Azelaic acid?
    • Keratolytic
    • Inhibits anaerobic glycolysis (weak antibiotic)
    • Scavenger of oxygen free radicals (weak anti-infalmmatory)
  27. What are the side effects of Azelaic acid?
    • Irritation, Itching
    • Hypopigmentation- anti-tyrosinase and anti-mitochondrial enzymatic activities may interupt activity of normal melanocytes OR free radical scavengers cause hyperactivity of melanocytes
    • Transient--resolve in 1-2 weeks
  28. When to use azelaic acid?
    • mild to moderate acne
    • mono- for mild
    • combo- for none responding mild OR in combo for moderate
  29. What are the directions for azelaic acid?
    • Apply twice daily
    • see improvement in 1-2 months and continued over several months if needed
  30. What is the Preg Category of azelaic acid?
    B
  31. When should azelaic acid be used?
    12 yrs

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