Self Care- Acne Treatment (keratolytics)

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  1. What are (7) non-pharmacological treatments of acne?
    • wash face twice daily (mild soap/cleanser)
    • avoid oily skin products
    • avoid squeezing/manipulating lesions
    • stay well hydrated
    • pore strips
    • oil absorbing strips
  2. What's the mechanism of action of Soap?
    removal of excess sebum & oil---lipohilic center & hydrophilic heads
  3. What are the side effects of soap?
    excessive drying/peeling
  4. What are the (5) Keratolytics?
    • Benzoyl peroxide
    • Salicylic acid
    • Sulur compounds
    • Resorcinol
    • Azelaic acid
  5. What is the MOA of benzoyl peroxide?
    • Keratolytic- breaks up keratin
    • Exfoliative- Desquamation
    • Comedolytic- solubilizes proteins
    • Bactericidal- oxygen radicals (dibenzoic acid)
  6. What are the side effects of benzoyl peroxide?
    • irritation, drying, peeling, erythema
    • bleaching
    • contact dermatitis- with 1st application
    • photosensitivity
  7. When to use benzoyl peroxide in therapy?
    • mild acne- monotherapy
    • moderate to severe- in combination
  8. What are the benzoyl peroxides directions?
    • Apply once to twice daily to clean, dry skin
    • 30 min after washing face
    • Titrate- test patch 15 min, then double time for each application until reach 4 hrs. Then try overnight then more than once a day.
  9. What is the Preg Category for BPO?
  10. What is the age for BPO?
    greater than 12yrs
  11. What is the MOA for salicylic acid?
    • Kearatolytic
    • Solubilizes intracellular cement
    • decreases corneocyte adhesion
    • Desquamation
    • Comedolytic
  12. What are the side effects of salicylic acid?
    • irritation
    • inflammation
    • erythema
    • salicylism---N/V/D, tinnitis, dizzieness (rare w/ topical)
  13. When to use salicylic acid?
    mild acne- less efficacious, fewer side effects, easier to use
  14. What are the directions for salicylic acid?
    Apply 1-3 times daily to clean dry skin (do not need to titrate but can for dryness)
  15. What is the Preg Category for salicylic acid?
  16. What age can salicylic acid be used?
    greater than 12yrs
  17. What is the MOA for sulfur compounds?
    • Keratolytic
    • Desquamation
    • Unproven Antibacterial effects
  18. What are the side effects of sulfur compounds?
    • stain
    • odor
    • comedogenic- triggers comedone formation
  19. Where are sulfur compunds most commonly found?
    with sulfonamides
  20. When are sulfur compunds used?
    • 2nd line in mild acne
    • use limited to side effects
  21. What are the directions of sulfur compounds?
    Apply 1-3 times daily
  22. What is the Preg Category of sulfur compounds?
  23. What age can sulfur compounds be used?
    greater than 12ys
  24. When is Resorcinol used?
    • in combo with sulfur
    • enhances the keratolytic effects of sulfur
  25. What are the side effects of Resorcinol?
    reversible brown scaling of skin
  26. What is the MOA of Azelaic acid?
    • Keratolytic
    • Inhibits anaerobic glycolysis (weak antibiotic)
    • Scavenger of oxygen free radicals (weak anti-infalmmatory)
  27. What are the side effects of Azelaic acid?
    • Irritation, Itching
    • Hypopigmentation- anti-tyrosinase and anti-mitochondrial enzymatic activities may interupt activity of normal melanocytes OR free radical scavengers cause hyperactivity of melanocytes
    • Transient--resolve in 1-2 weeks
  28. When to use azelaic acid?
    • mild to moderate acne
    • mono- for mild
    • combo- for none responding mild OR in combo for moderate
  29. What are the directions for azelaic acid?
    • Apply twice daily
    • see improvement in 1-2 months and continued over several months if needed
  30. What is the Preg Category of azelaic acid?
  31. When should azelaic acid be used?
    12 yrs
Card Set:
Self Care- Acne Treatment (keratolytics)
2011-12-12 02:17:37
pharmacy acne

Fall 2011 PT Module III: Acne
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