Self Care- Acne Treatment (Retinoids)

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Author:
mwill222
ID:
122889
Filename:
Self Care- Acne Treatment (Retinoids)
Updated:
2011-12-12 18:54:39
Tags:
pharmacy acne
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Description:
Fall 2011 PT Module III: Acne
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  1. What is retinol a precursor for?
    • Retinal
    • Retinoic acid
  2. Retinoic acid is an endogenous ligand for _________________ and _____________________________.
    • Retinoic acid receptors (RARs)
    • Retinoic acid receptors (RXRs)
  3. When retinoic acid and RARs make a complex they form a _______________________ factor.
    transcription
  4. What is the function of the RA/RAR ligand/receptor complex?
    • binds directly to DNA gene promoter regions
    • Regulates gene transcirption (by regulating translation of mRNA into protein)
  5. What are the characteristics of 1st & 2nd generation retinoids?
    • Flexible backbones
    • May bind several retinoid receptors
    • Greater side effects
  6. What are teh characteristics of 3rd generation retinoids?
    • More rings= less flexible
    • Interacts with fewer retinoid receptors
    • Mild side effect profile
  7. What is the MOA of Tretinoin (Retin A)?
    • Binds to RARs
    • Exfoliative (Inc Mitosis- dec. cell adhesion, exfoliative, dessquamation, keratolysis)
    • Inflammation (Inc. Prostaglandid E2- vasodilation, intracell edema)
  8. What are the side effects of Tretinoin?
    • Irritation, Erythema, Peeling, Dryness
    • "worsening of acne"
    • Photosensitivity
    • Anti-wrinkle effect- vasodilation and inc. collagen
  9. What kind of acne is Tretinoin used for?
    mild to moderate
  10. How do you use Tretinoin?
    • Apply to affected area once daily at bedtime (can start every other night)
    • Increase strength only after 4-6 weeks of lowest concentration
    • Full effect in 3-4 months
  11. When do you see the full effect of TRetinoin?
    3-4 months
  12. What is the Preg Category of Tretinoin?
    C
  13. In what ages can Tretinoin be used?
    greater than 12ys
  14. Which retinoid is a derivative of napthoic acid?
    • Adapalene (Differin)
    • similiar to 3rd generation retinoids
  15. What is the MOA of Adapalene?
    • binds to nuclear retinoic acid receptors
    • uncharacteristic anti-inflammatory actions
  16. What kind of acne is adapalene used to treat?
    mild to moderate
  17. How do you use adapalene?
    apply once daily at bedtime
  18. What is the pregnancy cetegory of adapalene?
    C
  19. In what ages can adapalene be used?
    greater than 12
  20. What retinoid will least likely have an acne flare up on inititiation?
    adapalene
  21. What is the active form of Tazarotene (Tazorac)?
    taxarotenic acid
  22. What generation retinoid is tazarotene is most similiar to?
    • third
    • milder side effect profile
  23. What is the MOA of tazarotene?
    • Binds to smaller # of RARs
    • Exfolliative-- differentiation--blocks orthinine decarboxylase
    • Kerotylitic
    • Anti-Inflammatory
  24. What kind acne is tazarotene used for?
    mild to moderate
  25. How do you apply tazarotene?
    once at bedtime
  26. What is the Preg Category of tazarotene?
    X
  27. In what ages can tazarotene be used?
    greater than 12ys

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