BMS - Immuno2

Card Set Information

Author:
Anonymous
ID:
123203
Filename:
BMS - Immuno2
Updated:
2011-12-13 01:30:23
Tags:
Immuno2
Folders:

Description:
Immuno 2
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. corticosteroids
    • Medrol
    • reduce the number of circulating lymphocytes
    • reduce chemotaxis
    • diminish MHC Class II molecules
    • reduce macrophage production of IL-1, which reduces IL-2 secretion by TH1 cells
    • stimulate synthesis of lipocortins (annexins) -> inhbit phospholipase A2 -> inhibiting production of PAF, prostaglandins, leukotrienes
    • stabilize lysosomal membranes
    • intefere with the cell cycle of lymphocytes
    • diminish COX-II
    • major adverse effects include infections, salt & water retention, potassium excretion, adrenal suppression
    • white blood cells don't increase and no increase in fever when on steroids
    • steroid psychosis can lead to dopamine increase
  2. cyclosporine
    • fat soluble cyclic polypetide antibioitc consisting of 11 amino acids
    • cyclosporine USP modified; lipid microemulsion ~ 60% p.o. bioavailability; 2X bioavailablitly than SandImmune (you would use less Neoral, because it's more bioavailable)
    • cyclosporine USP modified is NOT generically equivalent to cyclosporine USP
    • binds to cytoplasmic immunophilin (cyclophilin) which ultimately interferes with the production of a nuclear transcription factor invovled in the gene trascription of IL-2 and INF-gamma
    • inhibits the activation of proliferation (TH1 cells)
    • MOA: binds to cyclophillin and the complex inhibits calcineurin, thereby diminishing the gene expression of IL-2, IL-3, and IFN-gamma (among other cytokines) - calcineurin inhibitor
    • extensively metabolized by hepatic CYP3A enzymes
    • Indications: allogenic transplants, RA, severe recalcitrant psoriasis, "dry eye syndrome" - tears suppressed due to ocular inflammation
    • nephrotoxicity (elevated creatinine and BUN) is a major adverse effect
  3. tacrolimus [FK506]
    • MOA: binds to specific immunophilin FKBP (FK binding protein-12; FKBP-12) and then the complex inhibits calcineurin, thereby diminishing the gene expression of IL-2, IL-3, and IFN-gamma (among other cytokines) - calcineurin inhibitor
    • Indication: allogenic transplants - rejection of prophylaxis of allogeneic liver, kidney, heart transplants; atopic dermatitis (eczema) - Type I hypersensitivity
    • Unlabeled Uses: treatment of autoimmune disease and graft vs. host disease (GVHD), Crohn's Disease
    • macrolide (macrocyclic lactone) immunosuppressant
    • Not used for bacterial infection
    • inhbits TH1 cell activation
    • Major adverse effects: nephrotoxicity, hyperkalemia, hyperglycemia, neurotoxicity
    • increase side effects will occur b/c renal dysfunction and drug interactions

What would you like to do?

Home > Flashcards > Print Preview