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Self Care- Acne Treatment (Isotretinoin)
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What is the active form of Isotretinoin?
cis-
Retinoic Acid
What is the MOA of Isotretinoin?
Binds RARs (mech unknown)
Dec. Hyperkeratization (normalize follicular epithelium)
Dec. Sebum production
Dec. P. Acnes
Dec. inflammation
What is dosage of isotretinoin?
0.5-1mg/kg per day
2mg/kg per day for severe risk of scarring&disfigurement acne
x5 months= cum 120-150mg/kg per regimen
How do you monitor Isotretinoin?
Liver fxn tests, lipid panel (baseline, week #4 & #8)
CBC & CMP (Baseline)
Depression s/sx
Preg test (2 negative tests first then monthly)
What are the side effects of Isotretinoin?
Dry skin/peeling
Pruritis
Dry eyes (conjunctivitis)
Nosebleeds
Alopecia
Joint pain
Inc. LDL, Dec. HDL
Psychological
When do you use Isotretinoin?
Severe acne
Inflammatory acne not responding to typical treatments
How long does each course last?
15-20 weeks
When should retreatment start if needed?
2 months after last course
How many courses may be needed?
3-5
What is the approved age?
>12yrs
What is the pregnancy category?
X
What is drug interactions of isotretinoin?
Vit A supplements
Tetracyclines
How many forms of birth control must be used while on Isotretinoin?
2
Author
mwill222
ID
123257
Card Set
Self Care- Acne Treatment (Isotretinoin)
Description
Fall 2011 PT Module III: Acne
Updated
12/13/2011, 2:56:48 AM
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