Turnbull pharm & MOA

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Author:
lazzsant
ID:
123363
Filename:
Turnbull pharm & MOA
Updated:
2011-12-13 09:21:26
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MOA
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MOA pharm
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  1. Methotrexate
    Blocks DHFR -> decrease purine/ pyrimidine synth
  2. **Nephrotoxic & myelosuppressive
  3. 5- Fluorouracil
    inhibits thymidylate synthase --> no uridine --> dysfx RNA
  4. Hydroxyurea
    Inhibits ribonucleotide reductase
  5. Floxuridine
    -->FdUMP--> inhibit thymidylate --> DNA synthesis blocked
  6. Capecitabine
    --> 5-fluorouracil --> FdUMP--> inhibit thymidylate synthase--> dysfx RNA
  7. Mercaptopurine
    Inhibits purine nucleotide interconversions
  8. Cytarabine
    • AML DOC
    • Inhibits DNA polymerase
  9. Cyclophosphamide
    • CML & NHL
    • Converted to mustard(nephrotoxic) & acrolein(Mesna antidote)
  10. Carmustine
    • Lipophilic
    • CNS
  11. Doxorubicin & Daunorubicin
    Prevents topoisomerase from resealing helical breaks
  12. Dactinomycin
    Binds to DNA helix --> no transcription
  13. Bleomycin
    • Pulmonary fibrosis***
    • DNA fragementation
  14. Vincristine
    • Nerve toxicity***
    • prevents assembly of microtubules
  15. vinblastine
    • Myelosuppressive**
    • Inhibits assembly of microtubules
  16. Etoposide
    • For oat cell carcinoma of the lung
    • Breaks double strand by forming Topoisomerase 2-DNA complex stabilization
  17. Topotecan
    Topoisomerase I inhibitor
  18. Paclitaxel
    Inhibit microtubule disassembly
  19. Tamoxifen
    Blocks binding of estrogen to receptors in estrogen-receptor positive breast carcinoma
  20. Flutamide
    Nonsteroidal androgen antagonist
  21. Finasteride
    blocks 5-alpha reductase --> no DHT
  22. Leuprolide
    Partial agonist of GnRH receptor
  23. Trastuzumab
    binds HER2 in metastatic breast cancer
  24. Cisplatin
    diffuse into cells--> Cl- replaced by water
  25. Imatinib
    Inhibits BCR-ABL tyrosine kinase in CML
  26. Azathioprine
    • 6-thioinosinic acid inhibits PPRP enzymes --> no clonal expansion of B and T cells
    • prevents de novo synthesis of purine
  27. ALG
    Binds T cells --> complement destruction
  28. antithymocytic globulin
    • Acute renal transplant rejection crisis
    • cytotox ab to CDs 2, 3, 4, 8, 11a, 18, 25, 44, 45, HLA 1 &2
  29. Rho(D)
    Sequester all Rh+ ag --> no maternal ab
  30. Muromonab CD3
    ab to CD3 of thymocytes and mature T-cells
  31. cyclosporin
    • prevents prod and mobilization of IL-2 and IL-2 receptors in thymocyte
    • binds calcineurin which prevents Ca stimulated phosphatase activity --> no dephosphorylation of NF-AT --> no IL-2 transcription
  32. Tacrolimus
    complexes with FKBP --> no dephosph of NF-AT --> no IL-2 transcription
  33. Sirolimus
    • binds FKBP-12
    • binds and inhibits mTOR --> no G1-S progression
  34. mycophenolate mofetil
    inhibit monophosphate dehydrogenase --> no denovo guanine synthesis --> no B and T cells
  35. Etanercept
    receptor that binds TNF-a
  36. Infliximab
    neutralize TNF-a
  37. Daclizumab
    binds IL2 receptors --> no CD4 T cell activation
  38. Levamisole
    • Duke stage C colon cancer
    • Nephrotic syndrome
  39. INF-a
    • Hairy cell leukemia
    • hepatitis B & C
  40. IFN B
    Multiple sclerosis
  41. IFN Y
    • CGD
    • activate phagocytes
  42. Aldeslukein (IL2)
    • promotion of lymphoid cell differentiation into cytotoxic cells
    • activation of NK cells
  43. opreveleukin
    IL-11 --> platetlet formation
  44. Filgrastim
    granulocyte colony stimulating factor
  45. Sargramostin
    GM-CSF
  46. Epoetin-a
    RBC production
  47. Thrombopoetin
    Platelet production

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