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omi14
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What is free radical halogenation?
- Initiation:
 - Propagaation:
 - Termination: combination of any two radicals
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How do you calculate enthalpy?
ΔHº = (bonds broken) - (bonds formed)
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What is the relative selectivity of hydrogen in chlorination for 1º, 2º and 3º?
1:4.5:5.5
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What is the relative selectivity of hydrogen in bromination for 1º, 2º and 3º?
1:86:1700
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What is DMF?
- dimethylformamide
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What is DMSO?
- dimethyl sulfoxide
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What is an SN2 reaction?
- R-Nuc
- Backside attack
- inversion of configuration
- methyl>1º>2º
- good nucleophile/weak base
- good leaving group
- polar aprotic solvent
- second order reaction
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What is an SN1 reaction?
- R-Nuc
- carbocation intermediate
- inversion/retention of configuration
- 3º>2º
- weak nucleophile/weak base
- good leaving group
- polar protic solvent
- first order reaction
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What is an E1 reaction?
- Alkene is formed
- carbocation intermediate
- 3º>2º
- weak base/weak nuc
- good leaving group
- polar protic solvent
- first order reaction
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What is an E2 reaction?
- Alkene is formed
- H and leaving group must be anti and coplanar
- Zaitsev and Hofmann products form
- 3º>2º>1º
- strong base/good nuc
- good leaving group
- polar solvent
- second order reaction
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What is a Zaitsev product?
- Product with most substituted alkene
- More stable
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What is a Hofmann product?
- Product with the least substituted alkene
- Less steric hinderance in removal of H
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